Results 111 to 120 of about 42,092 (305)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Cutting Performance and Wear/Damage Characteristics of PCBN Tool in Hard Milling
Applied Sciences, 2019 In the intermittent machining of hardened steel for the die and mold industry, determining how to reduce the wear of PCBN (Polycrystalline Cubic Boron Nitride) tools and improve their machining efficiency and quality is an important subject.
Haining Gao, Xianli Liu, Zhitao Chen
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Bound states arising in Dirac fields are usually attributed to two kinds of features: domain walls where a real Dirac mass field changes sign, which host Jackiw-Rebbi states, and phase singularities in a complex Dirac mass field, which host Jackiw-Rossi zero modes.
Zhu, Bofeng +7 more
openaire +2 more sources
INVESTIGATIONS OF LASER CUTTING MODES ON THE QUALITY OF DIFFERENT CUT PARAMETERS
UNITECH – SELECTED PAPERSThis paper is a review article that details the parameters of laser cutting on the quality of the cut, considered as a critical factor of performance, aesthetics and functionality. For certain gauge sizes, two main thicknesses of low carbon steel sheet are considered in more detail in terms of tolerance accuracy.
Viktor Georgiev +2 more
openaire +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A novel haptic model and environment for maxillofacial surgical operation planning and manipulation
, 2012 This paper presents a practical method and a new haptic model to support manipulations of bones and their segments during the planning of a surgical operation in a virtual environment using a haptic interface. To perform an effective dental surgery it is
Arnez, Victor +14 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Wear of the cutting edge in the bandsawing operation when cutting austentic 17-7 stainless steel
, 2007 This paper reports on experimental data associated with forces, power and specific cutting energy associated with wear of high-speed steel bimetal bandsaw blades cutting 17-7 austenitic stainless steel bars.
Persson, Martin +2 more
core +1 more source
INFLUENCE OF PULSED LASER PROCESSING OF CARBIDE CUTTING TOOLS ON METAL CUTTING PERFORMANCE
Advanced Engineering Research, 2010 The results of influence of job stability and cutting instruments hardening on the process efficiency, job primecost and expenses for tools are described.
Igor A. PINAKHIN +2 more
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