Results 121 to 130 of about 391,162 (302)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Optimization of 5-Axis milling processes based on the process models with application to airfoil machining [PDF]

, 2007
5-axis milling is widely used in machining of complex surfaces such as airfoils. Improper selection of machining parameters may cause low productivity and undesired results during machining.
Budak, Erhan, Tunc, Taner
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Temperature dependent surface relaxations of Ag(111)

, 1998
The temperature dependent surface relaxation of Ag(111) is calculated by density-functional theory. At a given temperature, the equilibrium geometry is determined by minimizing the Helmholtz free energy within the quasiharmonic approximation. To this end,
A. Kara, C. Kittel, D. M. Ceperley, G. Helgesen, J. H. Cho, J. P. Perdew, J. W. M. Frenken, J. Xie, J. Xie, Jianjun Xie, K. H. Chae, K. Pohl, L. J. Lewis, M. Lazzeri, M. Methfessel, Matthias Scheffler, P. Giannozzi, P. Statiris, R. B. Doak, R. E. Allen, S. Baroni, S. Biernacki, S. Narasimhan, Stefano Baroni, Stefano de Gironcoli, X. Gonze, Y. Cao   +26 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Impact of cutting forces on surface quality in finish face milling of compacted graphite iron with CBN and nitride ceramic tools

Технічна інженерія
The article presents the results of studies to determine the influence of cutting forces on the quality parameters of machined surfaces as a result of finishing face milling of products made of compacted graphite cast iron (CGI) using round cutting ...
S.I. Radkevych
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Complex methods of treatment of pair of friction are in transmissions with dynamic loading [PDF]

, 2011
The new complex methods of treatment of surfaces of pair of frictions which will realize the features of processes of tooling on metal-cutting machine-tools are developed.
Pokintelica, Mykola, Strutinsky, Vasyl, Покінтелиця, Микола Іванович, Струтинський, Василь Борисович   +3 more
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Machining stability and machine tool dynamics [PDF]

, 2007
Machining is a common manufacturing process in industry due to its high flexibility and ability to produce parts which excellent quality. The productivity and quality in machining operations can be limited by several process constraints one of which is ...
Budak, Erhan
core