Results 101 to 110 of about 1,483,890 (296)

Smoky skies from the vast area of smouldering timber in the ACT ranges produced this golden sunset through the incinerated pines in Ingledene Forest, [21 January 2003] [picture] /

, 2003
Title from caption list supplied by the photographer, see file NLA04/564.; Part of the collection: A blood red noon, photography of the Brindabella & southern ACT fires of January 2003.; Also available in an electronic version via the Internet at: http://
Cutting, Jeff, 1945-
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A smoky sunset in the hills behind Narbethong on Smiths Road, from fire resident in the Clear Range and the Top Naas area, 21st January 2003 [picture] /

, 2003
Title from caption list supplied by the photographer, see file NLA04/564.; Inscriptions: Signed by the photographer in pencil on reverse; "25-15"--in pencil on reverse.; Part of the collection: A blood red noon, photography of the Brindabella & southern ...
Cutting, Jeff, 1945-
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Task force from the Hawkesbury District in NSW on standby for property protection along Smiths Road, as small runs of fire emerge from the Clear Range hills south of Tharwa, [21 January 2003] [picture] /

, 2003
Title from caption list supplied by the photographer, see file NLA04/564.; Part of the collection: A blood red noon, photography of the Brindabella & southern ACT fires of January 2003.; Also available in an electronic version via the Internet at: http://
Cutting, Jeff, 1945-
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

On the Physics of Machining Titanium Alloys: Interactions between Cutting Parameters, Microstructure and Tool Wear

Metals, 2014
The current work deals with the analysis of mechanisms involved during the machining process of titanium alloys. Two different materials were chosen for the study: Ti-6Al-4V and Ti-55531.
Mohammed Nouari, Hamid Makich
doaj   +1 more source

Effect of CO2 laser cutting process parameters on edge quality and operating cost of AISI316L [PDF]

, 2012
Laser cutting is a popular manufacturing process utilized to cut various types of materials economically. The width of laser cut or kerf, quality of the cut edges and the operating cost are affected by laser power, cutting speed, assist gas pressure ...
T. Inoue, Hagino, M., Olabi, Abdul-Ghani, A.G. Olabi, Eltawahni, Hayat, K.Y. Benyounis, H.A. Eltawahni, Benyounis, Khaled, Inoue, T., M. Hagino   +9 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source