Results 101 to 110 of about 1,505,269 (297)
Metals, 2014 The current work deals with the analysis of mechanisms involved during the machining process of titanium alloys. Two different materials were chosen for the study: Ti-6Al-4V and Ti-55531.
Mohammed Nouari, Hamid Makich
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Trudy Odesskogo Politehničeskogo Universiteta, 2013 At elongated holes boring several imperfections can occur, namely, the surface waviness and shape inaccuracies in the axial section. This research purpose is to establish the regularities of such imperfections formation depending on the technological ...
Борис Олегович Ткаченко +1 more
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Two-person pie-cutting: The fairest cuts [PDF]
Barbanel, Brams, and Stromquist (2009) asked whether there exists a two-person moving-knife procedure that yields an envy-free, undominated, and equitable allocation of a pie.
Brams, Steven J., Barbanel, Julius B.
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Ground of choice of cutting instruments and modes of cutting for cutters periodic action
, 2004 За допомогою ЕОМ виконано аналіз впливу геометричних параметрів ножа на основі порівняння результатів дослідження затрат енергії при подрібненні м’ясосировини ножами різних конструкцій.
Bortnik, A. +3 more
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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
INFLUENCE OF PULSED LASER PROCESSING OF CARBIDE CUTTING TOOLS ON METAL CUTTING PERFORMANCE
Advanced Engineering Research, 2010 The results of influence of job stability and cutting instruments hardening on the process efficiency, job primecost and expenses for tools are described.
Igor A. PINAKHIN +2 more
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