Results 91 to 100 of about 1,171,807 (293)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Журнал інженерних наук, 2018 Force modeling in metal cutting is important for various purposes, including thermal analysis, tool life estimation, chatter prediction, and tool condition monitoring.
Bashistakumar M., Pushkal B.
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Applied SciencesIn this study, a series of rock cutting tests was conducted using a conical pick to investigate the effect of joints on roadheader performance. Tests were performed on intact rock and jointed rock mass specimens with three different joint spacings.
Han-Eol Kim +3 more
doaj +1 more source
Point Cloud Classification by Domain Adaptation Using Recycling Max Pooling and Cutting Plane Identification. [PDF]
Sensors (Basel), 2023 Yoo H, Jun K.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Outer Approximation Algorithms for DC Programs and Beyond [PDF]
, 2008 We consider the well-known Canonical DC (CDC) optimization problem, relying on an alternative equivalent formulation based on a polar characterization of the constraint, and a novel generalization of this problem, which we name Single Reverse Polar ...
ZHANG, QINGHUA
core
Anisotropy of Single-Crystal Silicon in Nanometric Cutting
Nanoscale Research Letters, 2017 The anisotropy exhibited by single-crystal silicon in nanometric cutting is very significant. In order to profoundly understand the effect of crystal anisotropy on cutting behaviors, a large-scale molecular dynamics model was conducted to simulate the ...
Zhiguo Wang +4 more
doaj +1 more source