Results 221 to 230 of about 2,078,237 (349)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The effect of mixed fatigue on knee biomechanics and muscle activation during sidestep cutting in elite soccer players. [PDF]

BMC Sports Sci Med Rehabil
Chen K, Sun D, Chen D, Xuan B, Wang D, Song Y, Cen X, Jemni M, Fekete G, Gu Y.   +9 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Study on the Polishing Mechanism of Composite Magnetic Field-Controlled Internal Flow Channels in Additive Manufacturing. [PDF]

Materials (Basel)
Li H, Wang R, Zhang J, Guo S, Su G, Du J, Li B, Zhang P, Xia Y, Sun Y.   +9 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Successful pocket creation method using a multimodal device in endoscopic submucosal dissection for a colonic lateral spreading tumor. [PDF]

Endoscopy
Esaki M, Fukami N, Yamaguchi D, Hassan IH, Kim HJ, Jue TL.   +5 more
europepmc   +1 more source

Profound Leadership Strategies: Transcending the Leadership Crisis in the Age of Artificial Intelligence

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article examines the evolving role of organizational leadership amidst the rapid advancements in artificial intelligence (AI). It explores a broadly experienced and documented crisis in leadership, due in part to the disruptive nature of AI and emerging technology.
Rachel Wlodarsky, Davin Carr Chellman
wiley   +1 more source

3D guided large osteochondral allograft reconstructions for post-traumatic osteoarticular bone loss of the knee: a technical note. [PDF]

Eur J Trauma Emerg Surg
Assink N, van der Veen HC, Doornberg JN, Pijpker PAJ, IJpma FFA.   +4 more
europepmc   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Hybrid system design on reverse total shoulder arthroplasty glenoid components. [PDF]

JSES Rev Rep Tech
Dedeoğlu SS, Ayaz MB, Şahbat Y, İmren Y.   +3 more
europepmc   +1 more source