Results 61 to 70 of about 23,957 (296)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Projective Cutting-Planes for Robust Linear Programming and Cutting Stock Problems [PDF]
, 2022 International audienceWe explore the Projective Cutting-Planes algorithm proposed in Porumbel (2020) from new angles by applying it to two new problems, that is, to robust linear programming and to a cutting-stock problem with multiple lengths ...
Porumbel, Daniel
core +1 more source
Bayesian network learning with cutting planes [PDF]
, 2011 The problem of learning the structure of Bayesian networks from complete discrete data with a limit on parent set size is considered. Learning is cast explicitly as an optimisation problem where the goal is to find a BN structure which maximises log ...
James Cussens, Cussens, James
core +2 more sources
International Journal of Gerontology, 2009 Background: Precise left atrial (LA) volume quantification, representative of LA function, is of extraordinary clinical prognostic value. However, a detailed description of pathophysiology in different disease populations and interactions with aging by ...
Cheng-Ting Tsai +5 more
doaj +1 more source
Технічна інженерія, 2021 The wholeness of the stone monolith is saved when separating of it occur with the diamond wire machines. However, there are some problems and questions – what are the optimal dimensions of the monolith and the angles of drilling for contouring with ...
R.R. , N.M. , M.A. , V.V. , S.I.
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Revista Colombiana de Estadística, 2005 La regresión cuantílica es un problema de optimización convexa no diferenciable. Se examinan las ventajas y desventajas con relación a la necesidad de recursos de memoria y tiempo de cálculo de tres métodos clásicos de solución: dos de optimización ...
HÉCTOR MANUEL MORA ESCOBAR
doaj
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
On Chvátal Rank and Cutting Planes Proofs [PDF]
, 2003 We study the Chvátal rank of polytopes as a complexity measure of unsatisfiable sets of clauses. Our first result establishes a connection between the Chvátal rank and the minimum refutation length in the cutting planes proof system.
Jordi Levy +2 more
core
Cutting planes for multi-stage stochastic integer programs [PDF]
, 2006 This paper addresses the problem of finding cutting planes for multi-stage stochastic integer programs. We give a general method for generating cutting planes for multi-stage stochastic integer programs based on combining inequalities that are valid for ...
Nemhauser, George L. +5 more
core +1 more source