Results 51 to 60 of about 1,170,022 (307)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Influence of Thermal Treatment on Power Consumption during Plain Milling of Lodgepole Pine (Pinus contorta subsp. murrayana)

open access: yesBioResources, 2016
This paper investigated the energy consumption differences during plain milling of thermally treated and untreated lodgepole pine wood (Pinus contorta subsp. murrayana). Thermal treatment was completed at four temperatures, which were 160 °C, 180 °C, 210
Jiří Kubš   +6 more
doaj   +1 more source

Pengaruh Pemotongan Dengan Dan Tanpa Cairan Pendingin Terhadap Daya Potong Pada Proses Turning [PDF]

open access: yes, 2016
In this study whether the effect of cuts without using coolant differ significantly by cutting use liquid cooling to the power cut. To get the effect these cuts do testing on a lathe with a cutting speed varied.
Gede, I. N. (I)   +2 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Cutting Power during Milling of Thermally Modified Pine Wood

open access: yesDrvna Industrija, 2016
The paper presents experimental testing results of cutting power of thermally modified wood of Scots pine (Pinus sylvestris L.) during lengthwise milling. The process of heat treatment was performed in the atmosphere of superheated steam, at temperatures
Andrzej Krauss   +2 more
doaj   +1 more source

Optimization of the Cutting Parameters Affecting the Turning of AISI 52100 Bearing Steel Using the Box-Behnken Experimental Design Method

open access: yesApplied Sciences, 2022
In this study, we aimed to optimize the cutting parameters that affect the minimum temperature and power consumption in the turning of AISI 52100 bearing steel. For this, the Box-Behnken experimental design method, which was used for the lowest number of
Aytaç Yıldız   +2 more
doaj   +1 more source

Power-Law Graph Cuts

open access: yes, 2014
Algorithms based on spectral graph cut objectives such as normalized cuts, ratio cuts and ratio association have become popular in recent years because they are widely applicable and simple to implement via standard eigenvector computations. Despite strong performance for a number of clustering tasks, spectral graph cut algorithms still suffer from ...
Zhou, Xiangyang   +2 more
openaire   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Rugosidad superficial y potencia de corte en el cepillado de Acacia melanoxylon y Sequoia sempervirens Surface roughness and cutting power on Blackwood and Redwood planing

open access: yesMaderas: Ciencia y Tecnología, 2011
En el maquinado de madera, el cambio de las condiciones cinemáticas en el proceso de formación de viruta trae por consecuencia un cambio tanto en los esfuerzos de corte, como en el trabajo específico de corte, es decir, finalmente sobre la potencia de ...
Alfredo Aguilera, Hernán Muñoz
doaj  

Effect of cutting speed on cutting torque and cutting power of varying kenaf-stem diameters at different moisture contents [PDF]

open access: yes, 2015
This study focused on the development of an efficient cutting system for kenaf harvesters. Laboratory experiments were conducted on cutting kenaf stems of variety V36 using a rotary serrated cutting system. The Torque Trak 10k data acquisition system was
Abdan, Khalina   +3 more
core  

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