Results 171 to 180 of about 39,747 (262)

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Protocol for fixation and staining of postmortem human brain tissue optimized for focused ion beam-scanning electron microscopy. [PDF]

STAR Protoc
Maier MJ, Lewis DA, Freyberg Z, Glausier JR.   +3 more
europepmc   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

European forest carbon and biodiversity policies have a limited win-win potential. [PDF]

Nat Commun
Balducci L, Haeler E, Paillet Y, Alterio E, Ammer C, Archaux F, Boch S, Bouget C, Brazaitis G, Chianucci F, Cutini A, De Smedt P, Doerfler I, Dvořák D, Fischer M, Fischer M, Giordani P, Gosselin M, Heilmann-Clausen J, Holá E, Hofmeister J, Hošek J, García-Mijangos I, Janssen P, Jung K, Kepfer-Rojas S, Korboulewsky N, Kozák D, Kuras T, Lachat T, Malíček J, Mårell A, Mikoláš M, Müller J, Napoleone F, Nordén B, Ódor P, Palice Z, Schall P, Sitzia T, Šimkevičius K, Svoboda M, Tenčík A, Tinya F, Trentanovi G, Ujhazyova M, Vandekerkhove K, Wohlwend M, Weisser WW, Burrascano S.   +49 more
europepmc   +1 more source

Dynamic Regulation of Endogenous Transcription Factor Hubs at Single‐Molecule Resolution

Advanced Science, EarlyView.
This study combines single‐molecule microscopy and genome editing to characterize the dynamic behaviors of endogenous oncofusion transcription factor EWS::FLI1 in Ewing sarcoma cells. EWS::FLI1 forms neomorphic hubs that dynamically assemble and dissolve. The hubs are regulated during mitosis, by RNA, and by specific chemicals.
Shawn Yoshida, Yanghao Zhong, Akiko Kumagai, William G. Dunphy, Shasha Chong   +4 more
wiley   +1 more source

Rapid single-live-cell scanning <i>via</i> Fourier-transform infrared (FTIR) microscopy to elucidate microplastic-cell interactions. [PDF]

MethodsX
Friedrich HKJ, Alshareef OA, Wright SL, Cinque G, Chan KLA.   +4 more
europepmc   +1 more source

Stage‐Adaptive Janus Microneedle System for Redox‐Immune Regulation and Mitochondrial Protection in Infected Diabetic Wound Healing

Advanced Science, EarlyView.
ABSTRACT Infected diabetic wounds are sustained by a vicious cycle of hyperglycemia‐driven bacterial infection, persistent oxidative stress, and excessive inflammation, which collectively disrupt the ordered progression of tissue repair. Here, we engineered a stage‐adaptive Janus microneedle patch (MN‐FeSAC‐PPE) to enable a staged therapeutic process ...
Mengting Yin, Yu Zhang, Xinyu Qu, Jiayi Liu, Zhongyi Sun, Haibo Liu, Ziyan Chen, Jing Ru, Jingwen Han, Bingqiang Lu, Yan Lu, Yan Wang, Xinyu Zhao, Feng Chen   +13 more
wiley   +1 more source

Personalized Tibial Component Placement in Medial Unicompartmental Knee Arthroplasty: Surgical Technique and Rationale. [PDF]

J Clin Med
Queirazza P, Minelli M, Cacace F, Kon E, Arnaldi E, Basso M.   +5 more
europepmc   +1 more source

Neuromorphic Near‐Sensor and In‐Sensor Computing Enabled by Next‐Generation Material‐Based Sensors

Advanced Science, EarlyView.
This Review presents a structural framework that classifies neuromorphic sensing into near‐sensor and in‐sensor architectures, clarifying physical coupling between sensing and computation. The framework connects neural and synaptic device functions with recent advances in optical, mechanical, and chemical sensing, compares energy consumption and ...
Su Yeon Jung, Gwang Ya Kim, Sejin Kim, Hyunjong Seo, Se Gi Lee, Sang Min Won, Dongjoon Rhee, Joohoon Kang   +7 more
wiley   +1 more source

Study on Water-Jet-Guided Laser-Ultrasonic Grinding Hybrid Processing Technology for SiC_f/SiC Composite Materials. [PDF]

Materials (Basel)
Yu G, Zhang D, Pei X, Yang F.
europepmc   +1 more source