Results 131 to 140 of about 7,476,610 (346)

Using the Finite Element Method to Determine the Temperature Distributions in Hot-wire Cutting. [PDF]

, 2011
Hot-wire cutting is a common material removal process used to shape and sculpt plastic foam materials, such as expanded polystyrene (EPS). Due to the low cost and sculpt-ability of plastic foams they are popular materials for large sized (> 1 m³ ...
Aitchison, David, Brooks, Hadley Laurence   +1 more
core  

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Cutting Temperature Investigation of AISI H13 in High Speed End Milling

International Journal of Engineering Materials and Manufacture, 2016
Heat produced at the tool-chip interface during high speed milling operations have been known as a significant factor that affect to tool life and workpiece geometry or properties. This paper aims to investigate cutting temperature behaviours of AISI H13
Muhammad Riza, Erry Y. T. Adesta
doaj   +1 more source

Digital image correlation as a usefful tool of analysis of hot cutting process [PDF]

, 2013
This study deals with the use of Digital Image Correlation (DIC) to investigate the physical phenomena taking place during the orthogonal cutting of a SG iron specimen at high temperature (around 1,000 °C).
EL MANSORI, Mohamed, FOUILLAND-PAILLE, Laurence, MOULART, Raphaël   +2 more
core   +3 more sources

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Analysis and Measurement of Cutting Temperature under Steady State Cutting

Journal of the Japan Society of Precision Engineering, 1978
Temperature distribution on the flank face and rake face of a cutting tool is analyzed by using a finite element method developed in this study. The method enables one to compute the steady-state temperature distribution in both the workpiece material and cutting tool without repetition of computation. Experiments are carried out to verify the validity
Yongseong LEE, Kazuyuki HIRAMOTO, Toshio SATA   +2 more
openaire   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Influence de la température sur l’usinabilité du Ti-5-5-5-3 [PDF]

, 2010
The realization of aeronautic parts with strong mechanical properties requires the use of high performance materials. That’s why, some new materials are used for landing gears as refractory titanium (as Ti-5-5-5-3).
Baili, Maher, Dessein, Gilles, Lallement, Daniel, Sallabery, Julien, Wagner, Vincent   +4 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source