Results 121 to 130 of about 892,705 (358)
Molecular Oncology, EarlyView.Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova +26 more
wiley +1 more source
Discussion: “Cooling and Lubrication of Cutting Tools: Progress Report No. 1 of the Sub-Committee on Cutting Fluids of the A.S.M.E. Special Research Committee on Cutting of Metals” (Hersey, Mayo D., Ashman, G. H., Blood, B. H., Boston, O. W., De Leeuw, A. L., Yonkman, W., and Nichols, W. W., 1929, Trans. ASME, 51(8), pp. 47–56) [PDF]
, 1929 John C. Sharp +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
MESOSCOPIC SCALE MINIMUM CUTTING THICKNESS MODEL AND ANALYSIS
Jixie qiangdu, 2022 Aiming at the minimum cutting thickness existing in mesoscopic cutting process, the formation mechanism of the minimum cutting thickness was described, and the theoretical model of minimum cutting thickness based on tool edge radius and friction ...
ZHU JiaWei, LEI XiaoBao, ZHANG Tao
doaj
Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation
Molecular Oncology, EarlyView.Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza +5 more
wiley +1 more source
Cutting forces prediction: The experimental identification of orthogonal cutting coefficients [PDF]
FME Transactions, 2017 In this paper the cutting coefficients were identified applying the orthogonal cutting mechanics, which are used in the cutting forces and torque prediction. The experiments were performed for material combination of the workpiece (16MnCr5) and tool (HSS-
Popović Mihajlo +2 more
doaj
Suppression of tool wear by extremely short-duration cutting
Mechanical Engineering Journal, 2015 High-speed cutting has various advantages such as high material removal rates and reduction of machining time. However, the greatest problem of high-speed cutting is its excessive tool wear rate.
Yuki TERASAKA +3 more
doaj +1 more source
Process simulation for 5-axis machining using generalized milling tool geometries [PDF]
, 2010 Multi-axis machining (especially 5-axis machining) is widely used in precision machining for automotive, aerospace and die-mold manufacturing. The goal in precision machining is to increase production while meeting high part quality needs which can be ...
Budak, Erhan +2 more
core
WORK: A Journal of Prevention, Assessment & Rehabilitation, 2012 The paper presents the development of a cutting tool guide, specifically for the harvest of bamboo. The development was made based on precepts of eco-design and ergonomics, for prioritizing the physical health of the operator and the maintenance of the environment, as well as meet specific requirements of bamboo.
Mariana Bezerra +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source