Results 121 to 130 of about 900,172 (360)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Optimization of End Mill Geometry for Machining 1.2379 Cold-Work Tool Steel Through Hybrid RSM-ANN-GA Coupled FEA Approach

Machines
Optimizing end mill geometry is critical for improving performance and reducing costs in the high-volume manufacturing of tools, dies and molds. This study demonstrates a successful optimization framework for solid end mills machining 1.2379 cold-work ...
Tolga Berkay Şirin, Oguzhan Der, Hasan Kuş, Çağla Gökbulut Avdan, Semih Yüksel, Ayhan Etyemez, Mustafa Ay   +6 more
doaj   +1 more source

Non-uniform sampling finite-time control for networked control systems via event-driven transmission

Advances in Mechanical Engineering, 2016
This article investigates the networked finite-time control problem for a class of continuous-time linear systems. A novel event-driven data transmission scheme is invoked to reduce the network loads.
Lijia Liu, Xianli Liu, Yuanhong Liu
doaj   +1 more source

Monitoring Wears of Intelligent Cutting Tools [PDF]

, 2013
Import 26/06/2013Cílem této bakalářské práce je sledování opotřebení inteligentních řezných nástrojů. Břit nástroje je vyroben z řezné keramiky na bázi nitridu křemíku s nanesenou odporovou vrstvou.
Pomykacz, Adam
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Thermal stability and mechanical properties of (Al,Cr,Ti,Si,Y)N multielement nitride coatings after annealing

Journal of Materials Research and Technology
Although AlTiN is the preferred hard-coating material for cutting tools, its limited thermal stability causes problems at high cutting temperatures.
Jiaming Xu, Ping Zhang, Puyou Ying, Alexander Pogrebnjak, Chengzhi Ma, Changhong Lin, Tao Yang, Jianbo Wu, Tianle Wang, Andrei Ya Grigoriev, Vladimir Levchenko   +10 more
doaj   +1 more source

Optimization of broaching design [PDF]

, 2007
Broaching is one of the most recognized machining processes that can yield high productivity and high quality when applied properly. One big disadvantage of broaching is that all process parameters, except cutting speed, are built into the broaching ...
Budak, Erhan, Ozelkan, Ertunga, Ozturk, Ozkan, Özelkan, Ertunga, Öztürk, Özkan   +4 more
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Tribological properties of WS2 thin films with improved adhesion using MAIP/HiPIMS composite deposition

Journal of Materials Research and Technology
Dense WS2 thin films with excellent self-lubricating properties have been prepared using high-power impulse magnetron sputtering (HiPIMS) successfully.
Jianjian Yu, Ping Zhang, Puyou Ying, Chen Li, Changhong Lin, Tao Yang, Jianbo Wu, Tianle Wang, Nikolai Myshkin, Vladimir Levchenko   +9 more
doaj   +1 more source