Results 71 to 80 of about 838,874 (359)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Optimization for preparing Bi1.68Pb0.32Sr1.75Ca1.85Cu2.85O10+y powders by wet ball milling

Materials Research Express, 2022
Superconducting Bi _1.68 Pb _0.32 Sr _1.75 Ca _1.85 Cu _2.85 O _10+ _y (Bi-2223) powders were prepared by a conventional solid-state reaction using hand grinding and wet ball milling.
Yingwei Chen, Ling Shao, Guomeng Zhao, Qijie Liu, Yingqi Huang, Zhenzhong Liu, Liu Zhu, Tianle Wang, Beibei Zheng   +8 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Effect of Ratio of Nitrogen to Hydrogen on Microstructure and Wear Properties of Plasma Nitrided H13 Steel [PDF]

Cailiao Baohu
Aiming at the problem of early fatigue cracks in plasma nitrided H13 steel precision hot forging dies， plasma nitriding process tests were conducted under a nitriding temperature of 520 ℃， a pressure of 250 Pa and different nitrogen to hydrogen ratio ...
GAO Yuxin, WANG Junbo, CHENG Hu
doaj   +1 more source

Analytical prediction of stability limit in turning operations [PDF]

, 2006
Unstable cutting due to chatter vibrations is one of the most important problems during metal cutting operations. Chatter can be a limitation for productivity and surface quality in turning operations, especially when long and slender tools and parts are
Budak, Erhan, Ozlu, Emre, Özlü, Emre
core  

A comparative study of using spindle motor power and eddy current for the detection of tool conditions in milling processes [PDF]

, 2015
This paper investigates the use of the power of the driving motor of a CNC spindle in comparison to two perpendicular eddy current sensors for the detection of tool wear in milling processes. Monitoring the power through the current profile is a low cost
Abbass, JK, Al-Habaibeh, A
core   +1 more source

Laser Prepared Cutting Tools [PDF]

Physics Procedia, 2012
AbstractLaser pulses with a pulsewidth of a few picoseconds have recently received a lot of attention, solving the problem of manufacturing tools for new materials of superior mechanical properties. Processing thermally sensitive material, such as diamond and CBN structures, can be done without major material deterioration effects.
Dold Claus, Wegener Konrad, Henerichs Marcel, Walter Christian   +3 more
openaire   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Research on vibration reduction performance of dynamic vibration absorber based on damping characteristic of a new material

Advances in Mechanical Engineering, 2020
The absorbing effect of traditional dynamic vibration absorber (TDVA) is satisfactory only when the natural frequency is close to the excitation frequency.
Weizhi Song, Zhien Liu, Chihua Lu, Yongchao Li, Bin Li   +4 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source