Results 81 to 90 of about 123,340 (264)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Decomposition and segregation phenomena in PVD TiBN coatings

Materials & Design
TiBN coatings synthesized via physical vapor deposition (PVD) with a B content of 8 at.% and 25 at.% were investigated in terms of their phase and thermal stability, nanoscale composition and mechanical properties, using both experimental and theoretical
Alexander Reichmann, Christina Kainz, Nina Schalk, Tobias Spitaler, Michael Burtscher, Lorenz Romaner   +5 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Optimization of End Mill Geometry for Machining 1.2379 Cold-Work Tool Steel Through Hybrid RSM-ANN-GA Coupled FEA Approach

Machines
Optimizing end mill geometry is critical for improving performance and reducing costs in the high-volume manufacturing of tools, dies and molds. This study demonstrates a successful optimization framework for solid end mills machining 1.2379 cold-work ...
Tolga Berkay Şirin, Oguzhan Der, Hasan Kuş, Çağla Gökbulut Avdan, Semih Yüksel, Ayhan Etyemez, Mustafa Ay   +6 more
doaj   +1 more source

Non-uniform sampling finite-time control for networked control systems via event-driven transmission

Advances in Mechanical Engineering, 2016
This article investigates the networked finite-time control problem for a class of continuous-time linear systems. A novel event-driven data transmission scheme is invoked to reduce the network loads.
Lijia Liu, Xianli Liu, Yuanhong Liu
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Thermal stability and mechanical properties of (Al,Cr,Ti,Si,Y)N multielement nitride coatings after annealing

Journal of Materials Research and Technology
Although AlTiN is the preferred hard-coating material for cutting tools, its limited thermal stability causes problems at high cutting temperatures.
Jiaming Xu, Ping Zhang, Puyou Ying, Alexander Pogrebnjak, Chengzhi Ma, Changhong Lin, Tao Yang, Jianbo Wu, Tianle Wang, Andrei Ya Grigoriev, Vladimir Levchenko   +10 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Tribological properties of WS2 thin films with improved adhesion using MAIP/HiPIMS composite deposition

Journal of Materials Research and Technology
Dense WS2 thin films with excellent self-lubricating properties have been prepared using high-power impulse magnetron sputtering (HiPIMS) successfully.
Jianjian Yu, Ping Zhang, Puyou Ying, Chen Li, Changhong Lin, Tao Yang, Jianbo Wu, Tianle Wang, Nikolai Myshkin, Vladimir Levchenko   +9 more
doaj   +1 more source