Results 51 to 60 of about 16,254 (262)
Advances in Applied Mathematics, 1999 First of all in this paper some notions and terms are introduced: corner cut polyhedron \(P_n^d (\subset\mathbb{R}^d)\); \({\mathbb{N}^d \choose n}\) -- set of \(n\)-element subsets of \(\mathbb{N}^d\) (with nonnegative integer vectors); staircase; \({\mathbb{N}^d\choose n}_{\text{stair}}\) -- set of finite subsets of staircases from \({\mathbb{N}^d ...
Onn, Shmuel, Sturmfels, Bernd
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Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
The density of pine stands under intensive forest growing [PDF]
Сибирский лесной журнал, 2017 On permanent sample plots in young, middle-aged and mature, pure pine stands of the same age, the effectiveness of cuttings of different intensities was studied, to ensure intensive forest growing.
V. V. Ivanov +5 more
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Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Plantation-Seeding Forest Plantations – the New Method for Regeneration of Coniferous Forests at Large Clearings on Burned Lands [PDF]
Сибирский лесной журнал, 2014 The new method of restoration of coniferous stands on large felling areas on burnt lands that lack seed trees is discussed. It involves limited planting of big grafted seedlings of quality wood, that have a high level of seed production, with the purpose
V. V. Tarakanov +2 more
doaj
Folia Horticulturae, 2012 The growing of sage (Salvia officinalis L.) and balm (Melissa officinalis L.) in pots for the purpose of obtaining fresh culinary herbs was conducted during four terms from spring to autumn.
Capecka Ewa
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source