Results 71 to 80 of about 40,664 (309)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Computational Fluid Dynamics Study on the Effect of Drilling Parameters on Wellbore Cleaning in Oil Wells

Fuels
Poor wellbore cleaning is a significant challenge in oil drilling, primarily due to the accumulation of cuttings at the bottom of the well, particularly in deviated and horizontal wells.
Bachir Doghmane, Younes Hadj Guenaoui, Aimen Laalam, Habib Ouadi   +3 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Tropical and Subtropical Fruit Propagation

EDIS, 2019
Propagation is an important technique used by tropical and subtropical fruit growers worldwide, allowing plants to be grown cheaply and efficiently. While sexual propagation (by seed) results in plants that are not genetically the same as the mother ...
Jeff Wasielewski, Carlos F. Balerdi
doaj   +3 more sources

Stimulation of Striking Roots at the Cuttings of Laurel Tree (Laurus nobilis) with the Aid of Bioactive Substances of the Radistim Type

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2008
The laurel tree was first appraised as a decorative plant because of its persistent, glossy and agreeably nuanced leaves , as well as by its small yellow flowers grouped in panicles of an attractive aspect.
Mariana VLAD, I. VLAD
doaj   +1 more source

Cut and Paste

Journal of Computer and System Sciences, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Giansalvatore Mecca, Paolo Atzeni
openaire   +4 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Estacas de diferentes diâmetros na propagação de Lippia alba (Mill.) N.E.Br. - Verbenaceae Different diameters of cuttings on the propagation of Lippia alba (Mill.) N.E.Br. - Verbenaceae

Revista Brasileira de Plantas Medicinais, 2010
Este trabalho teve por objetivo avaliar o efeito de diferentes diâmetros de estacas na propagação de Lippia alba. Foram testadas estacas de 25 cm de comprimento, com diâmetros de 0,3-0,5 cm; 0,6-0,9 cm e 1-1,2 cm.
J.A. Marchese, E. Pissaia, V.C.C. Bocchese, E. Cambruzzi, G. Colussi, V. Hart, E.C. Magiero   +6 more
doaj   +1 more source

Type two cuts, bad cuts and very bad cut

Journal of Symbolic Logic, 1997
AbstractType two cuts, bad cuts and very bad cuts are introduced in [10] for studying the relationship between Loeb measure and U-topology of a hyperfinite time line in an ω1-saturated nonstandard universe. The questions concerning the existence of those cuts are asked there.
openaire   +2 more sources