Results 51 to 60 of about 54,606 (309)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

A Computational Fluid Dynamics Study on the Effect of Drilling Parameters on Wellbore Cleaning in Oil Wells

Fuels
Poor wellbore cleaning is a significant challenge in oil drilling, primarily due to the accumulation of cuttings at the bottom of the well, particularly in deviated and horizontal wells.
Bachir Doghmane, Younes Hadj Guenaoui, Aimen Laalam, Habib Ouadi   +3 more
doaj   +1 more source

The Final Cut

Journal of Philosophical Logic, 2022
AbstractIn a series of works, Pablo Cobreros, Paul Égré, David Ripley and Robert van Rooij have proposed a nontransitive system (call it ‘K3LP’) as a basis for a solution to the semantic paradoxes. I critically consider that proposal at three levels. At the level of the background logic, I present a conception of classical logic on which K3LP fails to ...
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Enraizamento de estacas foliares de violeta-africana (Saintpaulia ionantha Wendl.) em diferentes substratos Rooting of african violet (Saintpaulia ionantha Wendl.) in different substrate

Ciência e Agrotecnologia, 2005
O presente trabalho foi conduzido com objetivo de avaliar diferentes substratos no enraizamento de estacas foliares de violeta-africana (Saintpaulia ionantha Wendl). O trabalho foi desenvolvido em casa-de-vegetação, com tela de poliolefina 70%, no Centro
José Carlos Lopes, Marilda Torres Capucho, Ruimário Inácio Coelho, Alex Sandro Rodrigues Scandian   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Vertex Cuts

Journal of Graph Theory, 2014
AbstractGiven a connected graph, in many cases it is possible to construct a structure tree that provides information about the ends of the graph or its connectivity. For example Stallings' theorem on the structure of groups with more than one end can be proved by analyzing the action of the group on a structure tree and Tutte used a structure tree to ...
M. J. Dunwoody, Bernhard Krön
openaire   +4 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source