Results 1 to 10 of about 8,920 (149)

CX3C-chemokine receptor 1 modulates cognitive dysfunction induced by sleep deprivation [PDF]

Chinese Medical Journal, 2022
. Background:. Microglia plays an indispensable role in the pathological process of sleep deprivation (SD). Here, the potential role of microglial CX3C-chemokine receptor 1 (CX3CR1) in modulating the cognition decline during SD was evaluated in terms of ...
Jiawei Xin, Chao Wang, Xiaojuan Cheng, Changfu Xie, Qiuyang Zhang, Yilang Ke, Xuanyu Huang, Xiaochun Chen, Xiaodong Pan, Yanjie Yin, Xiuyuan Hao   +10 more
doaj   +4 more sources

An overview of the role of chemokine CX3CL1 (Fractalkine) and CX3C chemokine receptor 1 in systemic sclerosis [PDF]

Immunity, Inflammation and Disease
Introduction Systemic sclerosis (SSc) is a complex autoimmune disease characterized by fibrosis, vascular damage, and immune dysregulation. Fractalkine or chemokine (C‐X3‐C motif) ligand 1 (CX3CL1), a chemokine and adhesion molecule, along with its ...
Fatemehsadat Pezeshkian, Reza Shahriarirad, Hadiseh Mahram   +2 more
doaj   +4 more sources

The soluble G protein of respiratory syncytial virus promotes viral dissemination via TLR2-mediated NLRP3 priming and pyroptosis [PDF]

npj Viruses
Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections in infants, immunocompromised individuals, and older adults. Although vaccines and monoclonal antibodies have recently become available, understanding RSV pathogenesis ...
Robert Meineke, Ayse Agac, Marie-Christin Knittler, Albert D.M.E. Osterhaus, Martin Ludlow, Guus F. Rimmelzwaan   +5 more
doaj   +2 more sources

High expression of CX3C chemokine receptor 1 (CX3CR1) in human carotid plaques is associated with vulnerability of the lesions

Folia Neuropathologica, 2017
Introduction : In data based on ex vivo studies and animal models, fractalkine is considered an important mediator in the development and destabilization of atherosclerotic plaques.
Marta Masztalewicz, Przemysław Nowacki, Łukasz Szydłowski, Maciej Żukowski, Piotr Gutowski   +4 more
doaj   +3 more sources

Role of Common Fractalkine Receptor Variants with Chronic Hepatitis B Patients in Tunisia [PDF]

Viruses
Chronic hepatitis B virus (CHB) infection remains a leading cause of hepatic inflammation and damage. Several studies have suggested the significant role of CX3C chemokine receptor 1 (CX3CR1) in inflammatory damages.
Imene Ben Dhifallah, Kaouther Ayouni, Zeineb Belaiba, Bacem AlaDdine Razgui, Sahar Trabelsi, Henda Touzi, Amel Sadraoui, Walid Hammemi, Hela Hannachi, Amira Kebir, Slimane Ben Miled, Henda Triki   +11 more
doaj   +2 more sources

Treatment with an Anti-CX3CL1 Antibody Suppresses M1 Macrophage Infiltration in Interstitial Lung Disease in SKG Mice

Pharmaceuticals, 2021
CX3C Motif Chemokine Ligand 1 (CX3CL1; fractalkine) has been implicated in the pathogenesis of rheumatoid arthritis (RA) and its inhibition was found to attenuate arthritis in mice as well as in a clinical trial. Therefore, we investigated the effects of
Satoshi Mizutani, Junko Nishio, Kanoh Kondo, Kaori Motomura, Zento Yamada, Shotaro Masuoka, Soichi Yamada, Sei Muraoka, Naoto Ishii, Yoshikazu Kuboi, Sho Sendo, Tetuo Mikami, Toshio Imai, Toshihiro Nanki   +13 more
doaj   +1 more source

Native Low-Density Lipoproteins Act in Synergy with Lipopolysaccharide to Alter the Balance of Human Monocyte Subsets and Their Ability to Produce IL-1 Beta, CCR2, and CX3CR1 In Vitro and In Vivo: Implications in Atherogenesis

Biomolecules, 2021
Increasing evidence has demonstrated that oxidized low-density lipoproteins (oxLDL) and lipopolysaccharide (LPS) enhance accumulation of interleukin (IL)-1 beta-producing macrophages in atherosclerotic lesions.
Aarón N. Manjarrez-Reyna, Camilo P. Martínez-Reyes, José A. Aguayo-Guerrero, Lucia A. Méndez-García, Marcela Esquivel-Velázquez, Sonia León-Cabrera, Gilberto Vargas-Alarcón, José M. Fragoso, Elizabeth Carreón-Torres, Oscar Pérez-Méndez, Jessica L. Prieto-Chávez, Galileo Escobedo   +11 more
doaj   +1 more source

Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice

Scientific Reports, 2022
Fractalkine is one of the CX3C chemokine family, and it is widely expressed in the brain including the hypothalamus. In the brain, fractalkine is expressed in neurons and binds to a CX3C chemokine receptor 1 (CX3CR1) in microglia.
Namiko Kawamura, Goro Katsuura, Nobuko Yamada-Goto, Riho Nakama, Yuki Kambe, Atsuro Miyata, Tomoyuki Furuyashiki, Shuh Narumiya, Yoshihiro Ogawa, Akio Inui   +9 more
doaj   +1 more source

Orthopedic surgery-induced cognitive dysfunction is mediated by CX3CL1/R1 signaling

Journal of Neuroinflammation, 2021
Background Postoperative pain is a common phenomenon after surgery and is closely associated with the development of postoperative cognitive dysfunction (POCD).
Inja Cho, Jeong Min Kim, Eun Jung Kim, So Yeon Kim, Eun Hee Kam, Eunji Cheong, Minah Suh, Bon-Nyeo Koo   +7 more
doaj   +1 more source

Induction of CCL8/MCP-2 by mycobacteria through the activation of TLR2/PI3K/Akt signaling pathway. [PDF]

, 2012
Pleural tuberculosis (TB), together with lymphatic TB, constitutes more than half of all extrapulmonary cases. Pleural effusions (PEs) in TB are representative of lymphocytic PEs which are dominated by T cells.
Chen, Jianxia, Chen, Ling, Ernst, Joel, Fan, Lin, Ge, Baoxue, He, Xin, Hu, Haili, Kaufmann, Stefan HE, Liu, Haipeng, Liu, Zhonghua, Song, Peng, Weng, Dong, Xiao, Heping, Yang, Hong, Zheng, Ruijuan   +14 more
core   +9 more sources