Results 11 to 20 of about 8,959 (184)

Candidate Biomarkers for Crohn's Disease: Hub Genes and Regulatory miRNAs Identified by Bioinformatics Analysis. [PDF]

Biochem Res Int
Background Crohn’s disease (CD) is a chronic, complex inflammatory condition that can affect the entire digestive tract, most commonly the terminal ileum. The exact cause of CD remains unknown. Bioinformatics was used in this study to identify the differentially expressed genes (DEGs) and microRNAs (miRNAs) that show potential as diagnostic and ...
Wang H, Shen M.
europepmc   +2 more sources

Opposing Roles of Blood-Borne Monocytes and Tissue-Resident Macrophages in Limbal Stem Cell Damage after Ocular Injury

Cells, 2023
Limbal stem cell (LSC) deficiency is a frequent and severe complication after chemical injury to the eye. Previous studies have assumed this is mediated directly by the caustic agent.
Chengxin Zhou, Fengyang Lei, Mirja Mittermaier, Bruce Ksander, Reza Dana, Claes H. Dohlman, Demetrios G. Vavvas, James Chodosh, Eleftherios I. Paschalis   +8 more
doaj   +1 more source

Upregulation of CC chemokine ligand 18 and downregulation of CX3C chemokine receptor 1 expression in human T‐cell leukemia virus type 1‐associated lymph node lesions: Results of chemokine and chemokine receptor DNA chip analysis [PDF]

Cancer Science, 2007
Adult T‐cell leukemia/lymphoma (ATLL) is a human malignancy associated with human T‐cell leukemia virus type 1 (HTLV‐1). The pathological features of the lymph nodes of ATLL change from those of lymphadenitis to Hodgkin's‐like features and those of lymphoma.
Kei, Shimizu, Kennosuke, Karube, Fumiko, Arakawa, Yuko, Nomura, Hideki, Komatani, Kouhei, Yamamoto, Shiro, Yoshida, Ryosuke, Aoki, Yasuo, Sugita, Morishige, Takeshita, Koichi, Ohshima   +10 more
openaire   +2 more sources

Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions

Journal for ImmunoTherapy of Cancer, 2020
Background Natural killer (NK) cells play a crucial role in tumor immunosurveillance through their cytotoxic effector functions and their capacity to interact with other immune cells to build a coordinated antitumor immune response.
Diane Damotte, Laurence Zitvogel, Marco Alifano, Marie-Caroline Dieu-Nosjean, Gabriela Bindea, Jeremy Goc, Jules Russick, Pierre-Emmanuel Joubert, Mélanie Gillard-Bocquet, Carine Torset, Maxime Meylan, Florent Petitprez, Marie-Agnes Dragon-Durey, Solenne Marmier, Aditi Varthaman, Nathalie Josseaume, Claire Germain, Pierre Validire, Ludovic Fournel, Audrey Lupo, Isabelle Cremer   +20 more
doaj   +1 more source

Receptors for Respiratory Syncytial Virus Infection and Host Factors Regulating the Life Cycle of Respiratory Syncytial Virus

Frontiers in Cellular and Infection Microbiology, 2022
Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infections and responsible for a large proportion of mortality in children and the elderly. There are no licensed vaccines available to date.
Ziheng Feng, Ziheng Feng, Lili Xu, Lili Xu, Zhengde Xie, Zhengde Xie   +5 more
doaj   +1 more source

Uric Acid Has Direct Proinflammatory Effects on Human Macrophages by Increasing Proinflammatory Mediators and Bacterial Phagocytosis Probably via URAT1

Biomolecules, 2020
The relationship of uric acid with macrophages has not been fully elucidated. We investigated the effect of uric acid on the proinflammatory ability of human macrophages and then examined the possible molecular mechanism involved. Primary human monocytes
Camilo P. Martínez-Reyes, Aarón N. Manjarrez-Reyna, Lucia A. Méndez-García, José A. Aguayo-Guerrero, Beatriz Aguirre-Sierra, Rafael Villalobos-Molina, Yolanda López-Vidal, Karen Bobadilla, Galileo Escobedo   +8 more
doaj   +1 more source

CD Molecules Nomenclature 2025: Antibody Validation and Expression Profiling of Immune System G Protein-Coupled Receptors. [PDF]

Eur J Immunol
HLDA Workshops were established 40 years ago to develop a standardized CD molecule nomenclature for leukocyte cell‐surface molecules by comparing monoclonal antibodies (mAbs) produced by different laboratories and companies. The HLDA11 Workshop focused on validating G‐protein‐coupled receptors (GPCRs) targeting mAbs and assessing cell‐type‐specific ...
Fernández-Calles J, Kužílková D, Hedin F, Bakardjieva-Mihaylova V, Škvárová Kramarzová K, van Zelm MC, Cosma A, Kalina T, Engel P, Human Cell Differentiation Molecules (HCDM) organization.   +9 more
europepmc   +2 more sources

E6130, a Novel CX3C Chemokine Receptor 1 (CX3CR1) Modulator, Attenuates Mucosal Inflammation and Reduces CX3CR1+ Leukocyte Trafficking in Mice with Colitis [PDF]

Molecular Pharmacology, 2017
The chemokine fractalkine (CX3C chemokine ligand 1; CX3CL1) and its receptor CX3CR1 are involved in the pathogenesis of several diseases, including inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, rheumatoid arthritis, hepatitis, myositis, multiple sclerosis, renal ischemia, and atherosclerosis.
Hisashi, Wakita, Tatsuya, Yanagawa, Yoshikazu, Kuboi, Toshio, Imai   +3 more
openaire   +2 more sources

A guide to chemokines and their receptors [PDF]

, 2018
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A, Dyer DP, Garton KJ, Gupta SK, Hundelshausen P, Janssens R, Murphy PM, Sozzani S, Speck RF, Suan D, Woollard SM, Zheng Y   +11 more
core   +1 more source

Elevated expression of CX3C chemokine receptor 1 mediates recruitment of T cells into bone marrow of patients with acquired aplastic anaemia [PDF]

Journal of Internal Medicine, 2014
AbstractObjectiveAcquired aplastic anaemia (AA) is a T‐cell‐mediated, organ‐specific autoimmune disease characterized by haematopoietic stem cell destruction in the bone marrow. The exact molecular mechanism of T‐cell trafficking into the bone marrow is unclear in AA.
J, Ren, X Y, Hou, S H, Ma, F K, Zhang, J H, Zhen, L, Sun, Y X, Sun, Y L, Hao, Y F, Cheng, M, Hou, C G, Xu, M H, Zhang, J, Peng   +12 more
openaire   +2 more sources