Results 71 to 80 of about 8,959 (184)

STAT3 regulates NK and NKT cell differentiation through C-X3-C motif chemokine receptor 1  (CX3CR1) in hyper-IgE syndrome

Molecular Biomedicine
Mutations in the signal transducer and activator of transcription 3 (STAT3) gene are strongly associated with Hyper-IgE Syndrome (HIES), a rare immunodeficiency disorder characterized by elevated levels of IgE and recurrent infections.
Ju Liu, Jingzhi Yang, Jianing Tang, Hongxia Tang, Xin Dai, Peiyao Jin, Yanmei Huang, Zhenzhen Li, Ziyin Zhang, Xiaohuan Guo, Martin Bitzan, Xiaoling Yin, Chaohong Liu   +12 more
doaj   +1 more source

Molecular analysis of lymphoid tissue from rhesus macaque rhadinovirus-infected monkeys identifies alterations in host genes associated with oncogenesis.

PLoS ONE, 2020
Rhesus macaque (RM) rhadinovirus (RRV) is a simian gamma-2 herpesvirus closely related to human Kaposi's sarcoma-associated herpesvirus (KSHV). RRV is associated with the development of diseases in simian immunodeficiency virus (SIV) co-infected RM that ...
Ryan Douglas Estep, Aparna N Govindan, Minsha Manoharan, He Li, Suzanne S Fei, Byung S Park, Michael K Axthelm, Scott W Wong   +7 more
doaj   +1 more source

Identification and analysis of divergent immune gene families within the Tasmanian devil genome [PDF]

, 2015
Background: The Tasmanian devil (Sarcophilus harrisii) is being threatened with extinction in the wild by a disease known as devil facial tumour disease (DFTD).
Belov, Katherine, Cheng, Yuanyuan, Morris, Katrina M, Papenfuss, Anthony T, Warren, Wesley   +4 more
core   +3 more sources

The glia‐immune network: Astrocytes and oligodendrocytes as microglial co‐ordinators in health and disease

The Journal of Physiology, Volume 604, Issue 4, Page 1558-1574, 15 February 2026.
Abstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Verity F. T. Mitchener, Millie J. Thackray, I. Lorena Arancibia‐Cárcamo   +2 more
wiley   +1 more source

Развитие иммунного ответа при пневмонии, вызванной Klebsiella pneumoniae. Часть 3 [PDF]

, 2017
В статье на основании литературных данных освещена роль хемокинов и дефензинов в развитии иммунного ответа при пневмонии, вызванной Klebsiella pneumoniae.
Абатуров, А.Е., Никулина, А.А.   +1 more
core  

hiPSC‐Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial‐Like Cells

Glia, Volume 74, Issue 1, January 2026.
SCZ astrocytes display an increased pro‐inflammatory profile upon TNF‐α stimulation. Reactive SCZ astrocytes induce microglial‐like cells to assume a dystrophic phenotype. Reactive SCZ astrocytes limit iMGs' synaptoneurosome uptake and migration. ABSTRACT Neuroinflammation, particularly astrocyte reactivity, is increasingly linked to schizophrenia (SCZ)
Pablo L. Cardozo, Chia‐Yi Lee, Juliana P. S. Lacerda, Júlia S. Fahel, Pablo Trindade, Gabriela Vitória, Leonardo Chicaybam, Rafaela C. Cordeiro, Isaque J. S. de Faria, Nathália C. Silva, Yaovi M. H. Todjro, Joana C. do P. Maciel, Martin H. Bonamino, Luciene B. Vieira, Breno F. Cruz, Rodrigo Nicolato, Kristen J. Brennand, Stevens K. Rehen, Fabíola M. Ribeiro   +18 more
wiley   +1 more source

Computational Insights into the Interaction of the Conserved Cysteine-Noose Domain of the Human Respiratory Syncytial Virus G Protein with the Canonical Fractalkine Binding site of Transmembrane Receptor CX3CR1 Isoforms

Membranes
The human Respiratory Syncytial Virus (hRSV) stands as one of the most common causes of acute respiratory diseases. The infectivity of this virus is intricately linked to its membrane proteins, notably the attachment glycoprotein (G protein).
João Victor Piloto, Raphael Vinicius Rodrigues Dias, Wan Suk Augusto Mazucato, Marcelo Andres Fossey, Fernando Alves de Melo, Fabio Ceneviva Lacerda Almeida, Fatima Pereira de Souza, Icaro Putinhon Caruso   +7 more
doaj   +1 more source

Chemogenetic Regulation of CX3CR1-Expressing Microglia Using Gi-DREADD Exerts Sex-Dependent Anti-Allodynic Effects in Mouse Models of Neuropathic Pain

Frontiers in Pharmacology, 2020
Despite growing evidence suggesting that spinal microglia play an important role in the molecular mechanism underlying experimental neuropathic pain (NP) in male rodents, evidence regarding the sex-dependent role of these microglia in NP is insufficient.
Fumihiro Saika, Shinsuke Matsuzaki, Daichi Kobayashi, Daichi Kobayashi, Yuya Ideguchi, Tomoe Y. Nakamura, Shiroh Kishioka, Shiroh Kishioka, Norikazu Kiguchi   +8 more
doaj   +1 more source

Monocyte chemoattractant proteins in the pathogenesis of systemic sclerosis [PDF]

, 2017
Activation of the immune system and increased synthesis of extracellular matrix proteins by fibroblasts are hallmarks in the pathogenesis of SSc. The molecular mechanisms underlying the infiltration of inflammatory cells into the skin and the subsequent ...
Akhmetshina, A., Distler, J. H. W., Distler, O., Schett, G.   +3 more
core  

Unlocking the Power of CXCR2 Inhibition to Overcome Gemcitabine Resistance in Pancreatic Cancer

FASEB BioAdvances, Volume 8, Issue 1, January 2026.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer‐related mortality, characterized by intrinsic resistance to conventional therapies and limited effective treatment options. In this study, we investigated the role of the CXCR2 axis in PDAC therapy resistance.
Caitlin Molczyk, Reegan Sturgeon, Sugandha Saxena, Esther Johnson, Rakesh Bhatia, Namita Bhyravbhatla, Sushil Kumar, Surinder K. Batra, Rakesh K. Singh   +8 more
wiley   +1 more source