Results 1 to 10 of about 17,558 (136)

Sirtuin 3 promotes microglia migration by upregulating CX3CR1 [PDF]

Cell Adhesion & Migration, 2019
We studied the role of Sirtuin 3 (SIRT3) in microglial cell migration in ischemic stroke. We used a middle cerebral artery occlusion (MCAO) model of focal ischemia.
Runjing Cao, Shiping Li, Junxiang Yin, Li Guo, Jiong Shi   +4 more
doaj   +3 more sources

Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity. [PDF]

PLoS ONE, 2015
Cx3cr1, the receptor for the chemokine Cx3cl1 (fractalkine), has been implicated in the progression and severity of Alzheimer's disease-like pathology in mice, but the underlying mechanisms remain unclear.
Jenny Dworzak, Benoît Renvoisé, Johnny Habchi, Emma V Yates, Christophe Combadière, Tuomas P Knowles, Christopher M Dobson, Craig Blackstone, Ole Paulsen, Philip M Murphy   +9 more
doaj   +4 more sources

CX3CR1 knockout aggravates Coxsackievirus B3-induced myocarditis. [PDF]

PLoS ONE, 2017
Studies on inflammatory disorders elucidated the pivotal role of the CX3CL1/CX3CR1 axis with respect to the pathophysiology and diseases progression. Coxsackievirus B3 (CVB3)-induced myocarditis is associated with severe cardiac inflammation, which may ...
Irene Müller, Kathleen Pappritz, Konstantinos Savvatis, Kerstin Puhl, Fengquan Dong, Muhammad El-Shafeey, Nazha Hamdani, Isabell Hamann, Michel Noutsias, Carmen Infante-Duarte, Wolfgang A Linke, Sophie Van Linthout, Carsten Tschöpe   +12 more
doaj   +3 more sources

Fractalkine/CX3CR1 Signaling Promotes Angiogenic Potentials in CX3CR1 Expressing Monocytes [PDF]

Blood, 2016
Abstract Introduction : Myelo-monocytic cells expressing CD11b are involved in angiogenesis, but their specific roles and underlying mechanisms are unclear. CX3CR1 is the only known receptor for fractalkine (Fkn). CD11b+CX3CR1+ cells isolated from ischemic muscles expressed F4/80, which is a common marker for mouse macrophages (Tissue (T)
Jeong A Kim, Jae-Yong Kwak, Yhim Eunjung, Joon Lee, Youngrok Park, Hal E. Broxmeyer   +5 more
openaire   +3 more sources

Fractalkine modulates pulmonary angiogenesis and tube formation by modulating CX3CR1 and growth factors in PVECs

Open Life Sciences, 2023
This study aimed to investigate effects of pulmonary fractalkine (FKN/CX3CL1) on angiogenesis and tube formation. Tube forming capability of pulmonary vascular endothelial cells (PVECs) was evaluated.
Liao Jun, Yang Xianwu, Yang Jiejie, Xiao Jingjing, Liu Xuyang, Zhuo Yingquan, Yang Jiafei, Gu Huajian   +7 more
doaj   +1 more source

CX3CR1 silencing-mediated macrophage polarization attenuates CCl4 -induced liver fibrosis in mice

陆军军医大学学报, 2022
Objective To investigate the role of CX3CR1 in liver fibrosis induced by CCl4 in mice. Methods The mice were divided into normal group (n=24), CCl4 group (n=36), CCl4+sh-NC group (n=36), and CCl4+sh-CX3CR1 group (n=36), and all the groups were induced ...
HUANG Shasha, ZOU Yanli, TAN Jie, LIU Meng, CHEN Wei   +4 more
doaj   +1 more source

Neuron–glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage [PDF]

Open Biology, 2013
An essential aspect of normal brain function is the bidirectional interaction and communication between neurons and neighbouring glial cells. To this end, the brain has evolved ligand–receptor partnerships that facilitate crosstalk between different cell
Graham K. Sheridan, Keith J. Murphy
doaj   +1 more source

Cx3cr1 controls kidney resident macrophage heterogeneity

Frontiers in Immunology, 2023
Kidney macrophages are comprised of both monocyte-derived and tissue resident populations; however, the heterogeneity of kidney macrophages and factors that regulate their heterogeneity are poorly understood. Herein, we performed single cell RNA sequencing (scRNAseq), fate mapping, and parabiosis to define the cellular heterogeneity of kidney ...
Alex Yashchenko, Sarah J. Bland, Cheng J. Song, Ummey Khalecha Bintha Ahmed, Rachel Sharp, Isabella G. Darby, Audrey M. Cordova, Morgan E. Smith, Jeremie M. Lever, Jeremie M. Lever, Zhang Li, Ernald J. Aloria, Shuja Khan, Bibi Maryam, Shanrun Liu, Michael R. Crowley, Kenneth L. Jones, Lauren A. Zenewicz, James F. George, Michal Mrug, Michal Mrug, David K. Crossman, Katharina Hopp, Stavros Stavrakis, Mary B. Humphrey, Mary B. Humphrey, Florent Ginhoux, Kurt A. Zimmerman   +27 more
openaire   +3 more sources

An overlooked subset of Cx3cr1 wt/wt microglia in the Cx3cr1 CreER-Eyfp/wt mouse has a repopulation advantage over Cx3cr1 CreER-Eyfp/wt microglia following microglial depletion

Journal of Neuroinflammation, 2022
Background Fluorescent reporter labeling and promoter-driven Cre-recombinant technologies have facilitated cellular investigations of physiological and pathological processes, including the widespread use of the Cx3cr1 CreER-Eyfp/wt mouse strain for ...
Kai Zhou, Jinming Han, Harald Lund, Nageswara Rao Boggavarapu, Volker M Lauschke, Shinobu Goto, Huaitao Cheng, Yuyu Wang, Asuka Tachi, Cuicui Xie, Keying Zhu, Ying Sun, Ahmed M. Osman, Dong Liang, Wei Han, Kristina Gemzell-Danielsson, Christer Betsholtz, Xing-Mei Zhang, Changlian Zhu, Martin Enge, Bertrand Joseph, Robert A. Harris, Klas Blomgren   +22 more
doaj   +1 more source

Fractalkine/CX3CR1 signaling during neuropathic pain [PDF]

Frontiers in Cellular Neuroscience, 2014
Chronic pain represents a major problem in clinical medicine. Whilst the acute pain that is associated with tissue injury is a protective signal that serves to maintain homeostasis, chronic pain is a debilitating condition that persists long after the inciting stimulus subsides.
Clark, Anna K., Malcangio, Marzia
openaire   +4 more sources