Results 91 to 100 of about 41,078 (248)
Advanced Science, EarlyView.This study shows TGM2 is upregulated in AP, impairing macrophage efferocytosis by inhibiting the STAT6–GAS6 axis. The lactoferrin‐modified, ROS‐responsive LF‐LNP@si‐TGM2 targets pancreatic macrophages, silences TGM2, restores the axis, and alleviates AP.
Xuxu Liu +8 more
wiley +1 more source
IBRO Reports, 2020 Patients with diabetes mellitus are predisposed to cognitive impairment. Fractalkine-CX3CR1 in the brain signaling represents a primary neuron-microglia inter-regulatory system for several brain functions including learning and memory processes.
Namiko Kawamura +5 more
doaj +1 more source
Fractalkine/CX3CR1-Dependent Modulation of Synaptic and Network Plasticity in Health and Disease
Neural Plasticity, 2023 CX3CR1 is a G protein-coupled receptor that is expressed exclusively by microglia within the brain parenchyma. The only known physiological CX3CR1 ligand is the chemokine fractalkine (FKN), which is constitutively expressed in neuronal cell membranes and
N. P. Camacho-Hernández +1 more
doaj +1 more source
Cutting Edge : Failure of Antigen-Specific CD4+ T Cell Recruitment to the Kidney during Systemic Candidiasis [PDF]
, 2014 Copyright © 2014 The Authors. Acknowledgments We thank E. Bolton and H. Bagavant for reagents and advice. We also acknowledge the staff of the Medical Research Facility at the University of Aberdeen for care of the animals used in this study.
Brown, Gordon D +5 more
core +2 more sources
Advanced Science, EarlyView.Polydopamine‐encapsulated probiotics restore gut homeostasis and reinstate macrophage efferocytosis, thereby reestablishing immune tolerance and mitigating systemic autoimmunity, highlighting a bioengineered microbiota‐based therapeutic strategy for SLE.
Ruimiao Wu +10 more
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Objectives We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine OA models that vary in severity of pathology and rate of progression, to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt +18 more
wiley +1 more source
Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice. [PDF]
PLoS ONE, 2018 Preterm labor (PTL) is the most common cause of neonatal death and long-term adverse outcome. The pharmacological agents for PTL prevention are palliative and frequently fail to prevent PTL and improve neonatal outcome.
Mika Mizoguchi +11 more
doaj +1 more source
Spatial Distribution of Macrophages During Callus Formation and Maturation Reveals Close Crosstalk Between Macrophages and Newly Forming Vessels [PDF]
, 2019 Macrophages are essential players in the process of fracture healing, acting by remodeling of the extracellular matrix and enabling vascularization. Whilst activated macrophages of M1-like phenotype are present in the initial pro-inflammatory phase of ...
Aulich, Linus +11 more
core +1 more source
Chemokines and atherosclerosis: focus on the CX3CL1/CX3CR1 pathway [PDF]
Acta Pharmacologica Sinica, 2013 Atherosclerosis is currently considered an inflammatory disease. Much attention has been focused on the potential role of inflammatory mediators as prognostic/diagnostic markers or therapeutic targets of atherosclerotic cardiovascular disease. CX3CL1 (or fractalkine) is a structurally and functionally unique chemokine with a well documented role in ...
Stavros, Apostolakis +1 more
openaire +2 more sources
Arthritis &Rheumatology, Accepted Article.Background Systemic lupus erythematosus (SLE) shows clinical and molecular heterogeneity, and cardiovascular (CV) complications and lupus nephritis (LN) remain leading causes of morbidity and mortality. This study investigated whether omic profiling can reveal molecular endotypes linked to these outcomes.
Tomás Cerdó +84 more
wiley +1 more source