Results 111 to 120 of about 41,078 (248)

Fractalkine is expressed in the human ovary and increases progesterone biosynthesis in human luteinised granulosa cells [PDF]

, 2011
Background: Recent evidence from rodent ovaries has demonstrated expression of fractalkine and the existence of fractalkine receptor, and showed that there is a significant increase in steroidogenesis in response to fractalkine, yet the role of ...
Shuo Huang, Ping Zhao, Liying Yang, Yuan Chen, Jie Yan, Enkui Duan, Jie Qiao   +6 more
core   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina

ASN Neuro, 2015
Fractalkine (CX3CL1 or FKN) is a membrane-bound chemokine expressed on neuronal membranes and is proteolytically cleaved to shed a soluble chemoattractant domain.
Sandra M. Cardona, Andrew S. Mendiola, Ya-Chin Yang, Sarina L. Adkins, Vanessa Torres, Astrid E. Cardona   +5 more
doaj   +1 more source

The immune cell landscape in kidneys of patients with lupus nephritis. [PDF]

, 2019
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from healthy control
Accelerating Medicines Partnership in SLE network, Anolik, Jennifer H, Apruzzese, William, Arazi, Arnon, Berthier, Celine C, Brenner, Michael B, Browne, Edward P, Buyon, Jill P, Chicoine, Adam, Dall'Era, Maria, Davidson, Anne, Diamond, Betty, Eisenhaure, Thomas M, Furie, Richard A, Hacohen, Nir, Hildeman, David A, Hoover, Paul J, Jonsson, A Helena, Kalunian, Kenneth C, Kamen, Diane L, Kretzler, Matthias, Lederer, James A, Li, Shuqiang, Lieb, David J, Liu, Yanyan, Massarotti, Elena, McInnis, Elizabeth A, Noma, Akiko, Nusbaum, Chad, Park, Meyeon, Payan-Schober, Fernanda, Pendergraft, William F, Petri, Michelle A, Putterman, Chaim, Rao, Deepak A, Raychaudhuri, Soumya, Slowikowski, Kamil, Smilek, Dawn E, Steelman, Scott, Sutherby, Danielle, Tosta, Patti, Wofsy, David, Woodle, E Steve, Zhang, Fan   +43 more
core  

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. [PDF]

, 2020
Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured sensory neurons in dorsal root ganglia (DRG).
Basbaum, Allan I, Braz, Joao M, Guan, Zhonghui, Hamel, Katherine A, Leff, Jacqueline, Liu, Hongju, Morvan, Maelig G, Yu, Stephen, Yu, Xiaobing   +8 more
core   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Epiblast-derived CX3CR1+ progenitors generate cardiovascular cells during cardiogenesis

The EMBO Journal
CX3CR1+ cells generate tissue macrophages in the developing heart and play cardioprotective roles in response to ischemic injuries in the adult heart. However, the origin and fate of CX3CR1+ cells during cardiogenesis remain unclear.
Kyuwon Cho, Mark Andrade, Saeed Khodayari, Christine Lee, Seongho Bae, Sangsung Kim, Jin Eyun Kim, Young-Sup Yoon   +7 more
doaj   +1 more source

Transcriptome-pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS. [PDF]

, 2018
Sporadic amyotrophic lateral sclerosis (sALS) is the most common form of ALS, however, the molecular mechanisms underlying cellular damage and motor neuron degeneration remain elusive.
Batra, Ranjan, Baughn, Michael W, Diaz-Garcia, Sandra, Hutt, Kasey, Kohl, Zacharias, Krach, Florian, Libby, Ryan T, Madrigal, Assael A, Pirie, Elaine, Rabin, Stuart J, Ravits, John, Rodriguez, Maria, Saberi, Shahram, Stauffer, Jennifer, Vu, Anthony Q, Wang, Ruth, Wheeler, Emily C, Winner, Beate, Yeo, Gene W   +18 more
core   +1 more source

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

Subsets of migrating intestinal dendritic cells [PDF]

, 2010
Dendritic cells (DCs) in the intestine are heterogeneous. Phenotypically different populations of conventional DCs have been identified in the intestinal lamina propria, Peyer's patches, and in the draining mesenteric lymph nodes, to which these DCs ...
Allan, Anjuere, Anjuere, Bedoui, Belz, Bimczok, Blazquez, Bollman, Brooke, Cavanagh, Cerovic, Chieppa, Chirdo, Cook, Coombes, Den Haan, Fleeton, Garside, Gowans, Hammerschmidt, Henri, Howard, Huang, Iliev, Iliev, Ionac, Iwasaki, Jaensson, Jakubzick, Jang, Jiang, Johansson-Lindbom, Kelsall, Liu, Liu, MacPherson, Macpherson, Maric, Massberg, Milling, Milling, Niess, Ochando, Pascale, Pham, Pugh, Qiu, Rescigno, Rhodes, Rhodes, Rhodes, Rimoldi, Salazar-Gonzalez, Shi, Smith, Steinman, Sun, Tilney, Turnbull, Uematsu, Viney, Wendland, Wilson, Worbs, Yoffey, Yrlid, Yrlid, Yrlid, Yrlid   +68 more
core   +1 more source