Results 161 to 170 of about 41,078 (248)

Midkine Overexpression Promotes Functional Recovery After Spinal Cord Injury by Enhancing Microglial Efferocytosis Via LRP‐1

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Midkine (MDK) promotes functional recovery after spinal cord injury by enhancing microglial efferocytosis, reducing neuroinflammation, and decreasing neuronal apoptosis. Overexpression of MDK activates the AKT/mTOR pathway, upregulates LRP‐1 and BDNF, and drives microglia toward an anti‐inflammatory phenotype.
Yu Wang, Lu Fang, Chenyuan Zhai, Jili Cai, Xiangzhe Li, Lijuan Zong, Yao Geng, Chenchen Zhu, Cheng Sun, Manyu Dong, Yilun Qian, Yan Liu, Ying Huang, Zun Wang, Tong Wang, Wen‐Tao Liu, Qi Wu   +16 more
wiley   +1 more source

38‐Marker Full‐Spectrum Flow Cytometry Panel for the Comprehensive Profiling of γδ T Cells in Human Blood and Lymphoid Tissues

European Journal of Immunology, Volume 56, Issue 3, March 2026.
This is an update to the Guidelines for the Use of Flow Cytometry and Cell Sorting in Immunological Studies (Third Edition), Chapter 12C, by Cossarizza et al. A 38‐marker full‐spectrum flow cytometry panel enabling high‐resolution profiling of human γδ T cells across blood and lymphoid tissues, including robust identification of rare, tissue‐adapted ...
Mohamed Hamed, Daniela Moreno‐Vicencio, Daniel Arsovski, Mustafa Farhat, Rosie Sanders, Ellen Mann, Annabelle Bennett, Priyanka Chevour, Martin S. Davey   +8 more
wiley   +1 more source

Depletion of Microglia Increases Cortical Oligodendrocyte Density During Remyelination

Glia, Volume 74, Issue 3, March 2026.
Cuprizone demyelination induces transient reactive states in deep cortical microglia (MG) through early recovery. Depleting MG in recovery increases the number of deep cortical mature/pre‐myelinating oligodendrocytes. Deep cortical reactive MG reduce oligodendrocyte density after demyelination.
Hannah Katherine Loo, Joseph Gallegos, Christine Mialki, Gregory E. Perrin, Thomas Malloy, Jennifer L. Orthmann‐Murphy   +5 more
wiley   +1 more source

MojoSort™ Mouse CX3CR1 Selection Kit Protocol v1

, 2016
This procedure is optimized for the isolation of 106 cells per test. If working with fewer than 106cells, keepvolumes as indicated for 106cells. For best results, optimize the conditions to your specific cell number andtissue. Prepare fresh MojoSort™ Buffer solution by diluting the 5X concentrate with sterile distilled water.
openaire   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Dynamic Retinal Pathology in Glaucoma Progression Revealed by High‐Resolution Functional Imaging In Vivo

Laser &Photonics Reviews, Volume 20, Issue 5, 6 March 2026.
In this work, we investigated the dynamic retinal pathology of glaucoma from onset to late stages through longitudinal in vivo high‐resolution imaging in a silicone oil‐induced ocular hypertension (SOHU) glaucoma mouse model. We developed an optimized adaptive optics two‐photon excitation fluorescence microscopy (AO‐TPEFM) technique for morphological ...
Yiming Fu, Pham Binh Minh, Sicong He, Yingzhu He, Zhongya Qin, Ting Xie, Jianan Qu   +6 more
wiley   +1 more source

Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions

MedComm, Volume 7, Issue 3, March 2026.
Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song, Yazhi Mo, Si Chen, Yuemei Chen, Chunying Zhang, Shanying Deng, Juan Liao, Yi He, Wei Wang, Weidong Zheng, Tingting Zeng   +10 more
wiley   +1 more source

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao, Wanning Liu, Yuanyuan Su, Yuxuan Ma, Xiaodi Zhao, Yuanyuan Lu   +5 more
wiley   +1 more source

Graphene Triggers Inflammation in Murine Microglia via Phagocytosis

Small Science, Volume 6, Issue 3, March 2026.
Phagocytosis of single‐layer graphene by microglia triggers inflammatory activation without cytotoxicity. Small carbon nanotubes elicit similar responses, whereas larger graphene nanoplatelets do not. Proteomic analysis reveals effects on inflammation, cytoskeleton, and proliferation, highlighting the importance of graphene stability for safe neural ...
Pratika Rai, Robert Subirana Slotos, Ahmar Hasnain, Emma Walter, Marina Mantellatto Grigoli, Irini Petrou, Mario Dejung, Jia‐Xuan Chen, Oliver Tüscher, Alexey Tarasov, Kristina Endres   +10 more
wiley   +1 more source

Female-specific <i>Cx3cr1</i>-driven regulation of ALS and Alzheimer's risk genes in tauopathy. [PDF]

Mol Neurodegener Adv
Sudwarts A, Thinakaran G.
europepmc   +1 more source