Results 11 to 20 of about 41,078 (248)

Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1

Disease Models & Mechanisms, 2019
Tendon disorders frequently occur and recent evidence has clearly implicated the presence of immune cells and inflammatory events during early tendinopathy. However, the origin and properties of these cells remain poorly defined.
Christine Lehner, Gabriel Spitzer, Renate Gehwolf, Andrea Wagner, Nadja Weissenbacher, Christian Deininger, Katja Emmanuel, Florian Wichlas, Herbert Tempfer, Andreas Traweger   +9 more
doaj   +1 more source

Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1I249/M280-expressing retina

Frontiers in Immunology, 2023
Diabetic retinopathy, a microvascular disease characterized by irreparable vascular damage, neurodegeneration and neuroinflammation, is a leading complication of diabetes mellitus.
Kaira A. Church, Kaira A. Church, Derek Rodriguez, Derek Rodriguez, Andrew S. Mendiola, Andrew S. Mendiola, Difernando Vanegas, Difernando Vanegas, Irene L. Gutierrez, Irene L. Gutierrez, Ian Tamayo, Abdul Amadu, Priscila Velazquez, Sandra M. Cardona, Sandra M. Cardona, Stefka Gyoneva, Stefka Gyoneva, Anne C. Cotleur, Richard M. Ransohoff, Richard M. Ransohoff, Richard M. Ransohoff, Tejbeer Kaur, Astrid E. Cardona, Astrid E. Cardona   +23 more
doaj   +1 more source

CX3CR1 Polymorphisms are associated with atopy but not asthma in German children [PDF]

, 2007
Chemokines and their receptors are involved in many aspects of immunity. Chemokine CX3CL1, acting via its receptor CX3CR1, regulates monocyte migration and macrophage differentiation as well as T cell-dependent inflammation.
Christian Vogelberg, Christophe Combadière, Combadiere C, Daoudi M, Davis CN, Erika von Mutius, Fraticelli P, Fujimoto K, Kormann MS, Laprise C, Martin Depner, Michael Kabesch, Michael S.D. Kormann, Moatti D, Niess JH, Norman Klopp, Rimaniol AC, Simpson A, Stephan K. Weiland, Thomas Illig, Tremblay K   +20 more
core   +2 more sources

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

Metabolic Effects of CX3CR1 Deficiency in Diet-Induced Obese Mice. [PDF]

PLoS ONE, 2015
The fractalkine (CX3CL1-CX3CR1) chemokine system is associated with obesity-related inflammation and type 2 diabetes, but data on effects of Cx3cr1 deficiency on metabolic pathways is contradictory.
Rachana Shah, Sean M O'Neill, Christine Hinkle, Jennifer Caughey, Stephen Stephan, Emma Lynch, Kate Bermingham, Gina Lynch, Rexford S Ahima, Muredach P Reilly   +9 more
doaj   +1 more source

Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1 [PDF]

, 2018
Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS) is the leading cause of non-traumatic neurological disability in young adults. Immune mediated destruction of myelin and oligodendrocytes is considered the
Araque, Pedronel, Cardona, Astrid E., Cardona, Sandra M., Church, Kaira A., Cleary, Ian A., Kim, Sangwon V., Mendiola, Andrew S., Parker-Thornburg, Jan, Ransohoff, Richard M., Saville, Stephen P., Soto-Ospina, Alejandro, Torres, Vanessa O., Watowich, Stephanie S.   +12 more
core   +3 more sources

Defective antitumor responses in CX3CR1‐deficient mice [PDF]

International Journal of Cancer, 2007
AbstractInnate immunity is critically important for tumor surveillance and regulating tumor metastasis. Fractalkine (FKN, CX3CL1), operating through the receptor CX3CR1, is an effective chemoattractant and adhesion receptor for NK cells and monocytes, important constituents of the innate immune response. Previous studies have shown that over‐expression
Yen-Rei A, Yu, Alan M, Fong, Christophe, Combadiere, Ji-Liang, Gao, Philip M, Murphy, Dhavalkumar D, Patel   +5 more
openaire   +2 more sources

Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs

eLife, 2021
Expression levels of CX3CR1 (C-X3-C motif chemokine receptor 1) on immune cells have significant importance in maintaining tissue homeostasis under physiological and pathological conditions.
Srinu Tumpara, Matthias Ballmaier, Sabine Wrenger, Mandy König, Matthias Lehmann, Ralf Lichtinghagen, Beatriz Martinez-Delgado, Elena Korenbaum, David DeLuca, Nils Jedicke, Tobias Welte, Malin Fromme, Pavel Strnad, Jan Stolk, Sabina Janciauskiene   +14 more
doaj   +1 more source

Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy. [PDF]

, 2018
Microglia are well known to play a critical role in maintaining brain homeostasis. However, their role in epileptogenesis has yet to be determined.
Adamo, Matthew A, Chang, Julia, Feustel, Paul, Gruenthal, Michael, Huang, Yunfei, Liao, Yuan, Mathern, Gary W, Mathur, Ramkumar, Mazurkiewicz, Joseph, Morgan, Shannon, Qian, Jiang, Ritaccio, Anthony L, Zhao, Xiaofeng, Zhu, Xinjun   +13 more
core   +2 more sources

Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons [PDF]

, 2006
We examined the effects of the chemokine fractalkine (CX3CL1) on EPSCs evoked by electrical stimulation of Schaffer collaterals in patch-clamped CA1 pyramidal neurons from rat hippocampal slices.
BERTOLLINI, Cristina, CHARO IF, DI ANGELANTONIO, SILVIA, EUSEBI, Fabrizio, GROSS C, LIMATOLA, Cristina, MAGGI, Laura, RAGOZZINO, Davide Antonio, TRETTEL, Flavia   +8 more
core   +1 more source