Results 231 to 240 of about 41,078 (248)

Fractalkine/CX3CR1 and atherosclerosis

Clinica Chimica Acta, 2011
Fractalkine is a unique chemokine which has both adhesive and chemoattractant functions. With the increasing emphasis on the importance of inflammation in atherosclerosis, more attention has been focused on the role of chemokines in atherosclerosis.
Hong, Liu, Deqian, Jiang
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The CX3CL1–CX3CR1 system and psoriasis

Experimental Dermatology, 2006
Abstract:  CX3CL1 is a chemoattractant and adhesion molecule that induces the redistribution of CX3CR1‐positive inflammatory leucocytes to sites of inflammation. As a consequence of their increased expression in plaques of psoriasis, and location within genomic regions previously linked to this disease, CX3CL1, and its receptor CX3CR1, represent ...
Plant, Darren, Young, Helen S., Watson, Rachel E B, Worthington, Jane, Griffiths, Christopher E M   +4 more
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Downregulation of CX3CR1 ameliorates experimental colitis: evidence for CX3CL1-CX3CR1-mediated immune cell recruitment

International Journal of Colorectal Disease, 2016
Inflammatory conditions like inflammatory bowel diseases (IBD) are characterized by increased immune cell infiltration. The chemokine ligand CX3CL1 and its receptor CX3CR1 have been shown to be involved in leukocyte adhesion, transendothelial recruitment, and chemotaxis.
Felix, Becker, Christina, Holthoff, Christoph, Anthoni, Emile, Rijcken, J Steven, Alexander, Felicity N E, Gavins, H U, Spiegel, Norbert, Senninger, Thorsten, Vowinkel   +8 more
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Distribution of CCR5-Δ32, CCR2-64I, SDF1-3′A, CX3CR1-249I, and CX3CR1-280M in Chinese Populations

AIDS Research and Human Retroviruses, 2008
Polymorphisms of CCR5, CCR2, SDF, and CX3CR1 were reported to be involved in HIV-1 infection or the development of disease progression to AIDS. Cohort studies showed that CCR5-Delta32, SDF1-3'A, and CCR2-64I were protective, which could provide resistance to HIV-1 infection or delay disease progression, although the effect of SDF1-3'A homozygosity in ...
Yuan, Qian, Hao, Sun, Keqin, Lin, Lei, Shi, Li, Shi, Jiayou, Chu   +5 more
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Relationship Between CX3CR1 Genetic Polymorphism and Carotid Atherosclerosis

Artificial Cells, Blood Substitutes, and Biotechnology, 2010
To investigate the possible association between V249I and T280M polymorphisms and carotid atherosclerosis (CAS) in a Han population in northern China we studied 328 patients with increased carotid artery intima-media thickness (C-IMT) and 292 healthy controls with normal C-IMT.
Renliang, Zhao, Yongjun, Wang, Ruowu, Shen, Yong, Sun   +3 more
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Fractalkine/CX3CR1 Signalling in Chronic Pain and Inflammation

Current Pharmaceutical Biotechnology, 2011
The development of new therapeutic approaches to the treatment of painful neuropathies requires a better understanding of the mechanisms that underlie chronic pain syndromes. There is increasing evidence that immune competent cells such as microglia contribute to the development of chronic pain states.
Clark, Anna K., Staniland, Amelia A., Malcangio, Marzia   +2 more
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[CX3CR1 polymorphism in patients with dilated cardiomyopathy].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2011
To investigate the association between CX3CR1 gene polymorphism and dilated cardiomyopathy (DCM).Two single nucleotide polymorphisms (SNP) rs3732378 (V249I) and rs3732379(T280M) in CX3CR1 gene were determined using PCR-RFLP. The frequencies of genotype and allele of these two SNPs were compared between 211 DCM patients and 211 normal controls.The ...
Xing-qiu, He, Yan-yun, Wang, Bin, Zhou, Li, Rao   +3 more
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Bone marrow-derived CX3CR1 progenitors contribute to neointimal smooth muscle cells via fractalkine CX3CR1 interaction.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010
Smooth muscle cells play a major role in numerous vascular diseases that contribute to remodeling, repair after injury, and arteriogenesis, and the source of these cells is thought to lie within the vessel wall and the circulating blood. Currently, the precise origin and mechanism of differentiation of extravascular smooth muscle progenitor cells (SPCs)
Kumar, A., Metharom, Pat, Schmeckpeper, J., Weiss, S., Martin, K., Caplice, N.   +5 more
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