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CX3CR1 as a target for airways inflammation.
Expert opinion on therapeutic targets, 2011Inflammation is a key component of asthma. Membrane-bound chemokine CX3CL1 is markedly induced on endothelial cells by inflammatory cytokines, and CX3CL1 levels are elevated in the bronchoalveolar lavage (BAL) of subjects with asthma. Recently, CX3CR1 (the receptor for CX3CL1) has been proposed as a target for airway inflammation, and the paper ...
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CX3CR1 Phenotypic Plasticity in Prostate Cancer Metastasis
We have previously reported that subsets of cancer cells (4-8%) expressing the chemokine receptor CX3CR1 on their surface (CX3CR1Surf+) are endowed with stemness features and behave as metastasis-initiating cells (MICs) when grafted in mice. We show that prostate cancer cells lacking surface CX3CR1 (CX3CR1Surf-) can re-express CX3CR1 on their surface ...Jieyi Zhang, Edward J. Hartsough
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