Results 21 to 30 of about 41,078 (248)

IFNβ-producing CX3CR1+ macrophages promote T-regulatory cell expansion and tumor growth in the APCmin/+ / Bacteroides fragilis colon cancer model

OncoImmunology, 2019
Increased T-regulatory cell activity drives tumor progression in the compound APCmin/+/enterotoxic Bacteroides fragilis colon cancer model. At the same time, how microbially-induced inflammation promotes T-regulatory cell expansion in the dysplastic ...
Tao Gu, Qingsheng Li, Nejat K. Egilmez
doaj   +1 more source

CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease

Molecular Neurodegeneration, 2022
Background Despite its identification as a key checkpoint regulator of microglial activation in Alzheimer’s disease, the overarching role of CX3CR1 signaling in modulating mechanisms of Aβ driven neurodegeneration, including accumulation of ...
Shweta S. Puntambekar, Miguel Moutinho, Peter Bor-Chian Lin, Vaishnavi Jadhav, Danika Tumbleson-Brink, Ananya Balaji, Martin Alvarado Benito, Guixiang Xu, Adrian Oblak, Cristian A. Lasagna-Reeves, Gary E. Landreth, Bruce T. Lamb   +11 more
doaj   +1 more source

CX3CR1+ Cell–Mediated Salmonella Exclusion Protects the Intestinal Mucosa during the Initial Stage of Infection [PDF]

, 2017
During Salmonella Typhimurium infection, intestinal CX3CR1(+) cells can either extend transepithelial cellular processes to sample luminal bacteria or, very early after infection, migrate into the intestinal lumen to capture bacteria. However, until now,
Angela L. Man, Claudio Nicoletti, Elizabeth Bassity, Eugenio Bertelli, Gary Rowley, Giovanna De Cunto, Man, Mari Regoli, Massimo Gulisano, Nadezhda Gicheva, Nicoletti, Nicoletti, Nikolaus Wellner   +12 more
core   +2 more sources

CX3CR1 expression and megakaryocytic series assessment on bone marrow biopsies in acquired aplastic anemia. Correlations with hematological parameters.

Romanian Journal of Laboratory Medicine, 2015
The study objective was to examine the clinical and hematological significance of receptor CX3CR1 and megakaryocytes in patients with aplastic anemia.
Gavrilut (Tomescu) Cosmina Ioana, Bondor Cosmina, Fetica Bogdan, Fulop Annamaria, Urian Laura, Petrov Ljubomir   +5 more
doaj   +1 more source

A novel interaction between CX3CR1 and CCR2 signalling in monocytes constitutes an underlying mechanism for persistent vincristine-induced pain

Journal of Neuroinflammation, 2018
Background A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing ...
Karli Montague, Raffaele Simeoli, Joao Valente, Marzia Malcangio   +3 more
doaj   +1 more source

Hypoxia-inducible factor-1α regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the CX3CR1 gene. [PDF]

PLoS ONE, 2012
CX3CR1 is an important chemokine receptor and regulates the chemotactic migration of pancreatic ductal adenocarcinoma (PDAC) cells. Up to now, its regulatory mechanism remains largely undefined.
Tiansuo Zhao, Song Gao, Xiuchao Wang, Jingcheng Liu, Yitao Duan, Zhanna Yuan, Jun Sheng, Shasha Li, Feng Wang, Ming Yu, He Ren, Jihui Hao   +11 more
doaj   +1 more source

The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances response to anti-PD-1 immunotherapy

Frontiers in Immunology, 2023
CX3CL1 secreted in the tumor microenvironment serves as a chemoattractant playing a critical role in metastasis of CX3CR1 expressing cancer cells. CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migration ...
Apoorvi Chaudhri, Apoorvi Chaudhri, Apoorvi Chaudhri, Apoorvi Chaudhri, Xia Bu, Xia Bu, Yunfei Wang, Michael Gomez, Michael Gomez, James A. Torchia, James A. Torchia, Ping Hua, Ping Hua, Shao-Hsi Hung, Shao-Hsi Hung, Michael A. Davies, Gregory A. Lizee, Ulrich von Andrian, Ulrich von Andrian, Ulrich von Andrian, Patrick Hwu, Gordon J. Freeman, Gordon J. Freeman   +22 more
doaj   +1 more source

To respond or not to respond - a personal perspective of intestinal tolerance [PDF]

, 2018
For many years, the intestine was one of the poor relations of the immunology world, being a realm inhabited mostly by specialists and those interested in unusual phenomena.
A Besredka, A Goubier, A Iwasaki, A Konrad, A Limmer, A Mortha, A Vaillant, AJ MacPherson, Allan McI. Mowat, AM Mowat, B Cassani, B Dubois, B Jabri, B Johansson-Lindbom, C Asseman, C Berlin, C Siewert, C Varol, CC Bain, CC Bain, CL Scott, CL Scott, CM Sun, CR Mackay, CR Stokes, D Esterhazy, D Fina, D Mucida, D Sichien, DP McGovern, DS Shouval, E Jaensson, E Jaensson-Gyllenback, E Mazzini, E Zigmond, EJ Kunkel, EM Nilsen, EM Nilsen, F Broere, F Ginhoux, F Hauet-Broere, F Powrie, FG Chirdo, G Lack, G Matteoli, G Mayrhofer, G Monteleone, GG MacPherson, H Arentz-Hanson, H Fukaura, H Tlaskalova, HG Wells, HL Klaasen, HL Weiner, HL Weiner, I Vicente-Suarez, ID Iliev, II Ivanov, J Farache, J Farache, JA Mattingly, JA Mattingly, JB Sun, JF Heremans, JH Niess, JL Coombes, JL Gowans, JL Viney, JM Blander, JP Hugot, JR Battisto, JR McDole, K Atarashi, K Atarashi, K Lahl, K Nagatani, K Takeda, KG McDonald, KM Luda, KM Smith, KP Zimmer, KS Kim, L Maiuri, L Maiuri, L Saurer, LA Hanson, LA Reynolds, LA Waaij van der, LM Sollid, M Boucard-Jourdin, M Butler, M Chieppa, M Karlsson, M Murai, M Rescigno, M Rimoldi, M Tsuji, M Yoshida, MH Jang, MH Jang, MO Li, MR Hepworth, MR Karlsson, MW Chase, N Korneychuk, N Satoh-Takayama, N Sudo, O Schulz, P Brandtzaeg, P Morrissey, PA Crabbe, PB Carter, PM Smith, R Bouziat, R Kuhn, R Zeng, R Zeng, RE Araya, RL Owen, RW DePaolo, S Hue, S Husby, S Husby, S Kawamoto, S Strobel, S Strobel, S Veenbergen, S Wilks, SI Hammerschmidt, SK Mazmanian, SV Kim, T Joeris, T Worbs, TB Tomasi Jr, TL Denning, U Hadis, V Cerovic, V Gaboriau-Routhiau, Y Chen, Y Cong, Y Ogura, ZM Falchuk, Ø Molberg   +142 more
core   +1 more source

Cx3cr1-deficient microglia exhibit a premature aging transcriptome [PDF]

Life Science Alliance, 2019
CX3CR1, one of the highest expressed genes in microglia in mice and humans, is implicated in numerous microglial functions. However, the molecular mechanisms underlying Cx3cr1 signaling are not well understood. Here, we analyzed transcriptomes of Cx3cr1-deficient microglia under varying conditions by RNA-sequencing (RNA-seq).
Stefka Gyoneva, Raghavendra Hosur, David Gosselin, Baohong Zhang, Zhengyu Ouyang, Anne C Cotleur, Michael Peterson, Norm Allaire, Ravi Challa, Patrick Cullen, Chris Roberts, Kelly Miao, Taylor L Reynolds, Christopher K Glass, Linda Burkly, Richard M Ransohoff   +15 more
openaire   +4 more sources

Indispensable Role of CX3CR1+ Dendritic Cells in Regulation of Virus-Induced Neuroinflammation Through Rapid Development of Antiviral Immunity in Peripheral Lymphoid Tissues

Frontiers in Immunology, 2019
A coordinated host immune response mediated via chemokine network plays a crucial role in boosting defense mechanisms against pathogenic infections. The speed of Ag presentation and delivery by CD11c+ dendritic cells (DCs) to cognate T cells in lymphoid ...
Jin Young Choi, Jin Hyoung Kim, Ferdaus Mohd Altaf Hossain, Ferdaus Mohd Altaf Hossain, Erdenebelig Uyangaa, Seong Ok Park, Bumseok Kim, Koanhoi Kim, Seong Kug Eo   +8 more
doaj   +1 more source