Results 41 to 50 of about 41,078 (248)
Redox Biology, 2019 TAU protein aggregation is the main characteristic of neurodegenerative diseases known as tauopathies. Low-grade chronic inflammation is also another hallmark that indicates crosstalk between damaged neurons and glial cells.
Sara Castro-Sánchez +3 more
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Revising CX3CR1 Expression on Murine Classical and Non-classical Monocytes
Frontiers in Immunology, 2020 In mice, monocytes (Mo) are conventionally described as CX3CR1low classical Mo (CMo) and CX3CR1high non-classical Mo (NCMo) based on the expression of EGFP in Cx3cr1+/EGFP mice and by analogy with human CX3CR1 expression.
Aïda Meghraoui-Kheddar +4 more
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CX3CR1(+) B Cells Show Immune Suppressor Properties [PDF]
Journal of Biological Chemistry, 2014 The immune regulatory functions of B cells are not fully understood yet. The present study aims to characterize a subtype of B cells that expresses CX3CR1. In this study, peripheral blood samples were collected from patients with food allergies and healthy subjects. Peripheral B cells were analyzed by flow cytometry.
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The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation
Frontiers in Integrative Neuroscience, 2020 According to the microglial hypothesis of schizophrenia, the hyperactivation of microglia and the release of proinflammatory cytokines lead to neuronal loss, which is highly related to the onset of schizophrenia.
Hao Zhou +4 more
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Ligand-competent fractalkine receptor is expressed on exosomes
Biochemistry and Biophysics Reports, 2021 Expression of chemokine receptor CX3CR1 is reportedly restricted to several cell types including natural killer cells, cytotoxic T cells, monocytes, and macrophages.
Eun Jeong Park +9 more
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Experimental rat models of chronic allograft nephropathy: a review [PDF]
, 2014 Chronic allograft nephropathy (CAN) is the leading cause of late allograft loss after renal transplantation (RT), which continues to remain an unresolved problem. A rat model of CAN was first described in 1969 by White et al. Although the rat model of RT
Haylor, John, Shrestha, Badri
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Association study between the CX3CR1 gene and asthma [PDF]
Genes & Immunity, 2006 CX3CR1, a fractalkine receptor, mediates cell-adhesive and migratory functions in inflammation. Based on CX3CR1 expression observed in bronchial tissues of asthmatic subjects, we hypothesized that genetic variation at this locus may affect susceptibility to asthma.
K, Tremblay +8 more
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Emerging Role of Fractalkine in the Treatment of Rheumatic Diseases
ImmunoTargets and Therapy, 2020 Yoshiya Tanaka,1 Kana Hoshino-Negishi,2 Yoshikazu Kuboi,2 Fumitoshi Tago,3 Nobuyuki Yasuda,2 Toshio Imai2 1First Department of Internal Medicine, University of Occupational and Environmental Health, Fukuoka, Japan; 2 KAN Research Institute Inc, Hyogo ...
Tanaka Y +5 more
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Absence of CX3CR1 impairs the internalization of Tau by microglia
Molecular Neurodegeneration, 2017 Background Extracellular Tau is toxic for neighboring cells, and it contributes to the progression of AD. The CX3CL1/CX3CR1 axis is an important neuron/microglia communication mechanism.
Marta Bolós +6 more
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Oncotarget, 2015 In a recent paper published in J. Ex. Med, we provided evidence that the knockout of CX3CR1 blocked the clearance of myelin debris by microglia, which greatly affected the integrity of axons and myelin sheaths, preventing proper remyelination. These results highlight the crucial role played by CX3CR1 in myelin removal and show that there can be no ...
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