Results 51 to 60 of about 41,078 (248)
CX3CL1/CX3CR1 in Alzheimer’s Disease: A Target for Neuroprotection [PDF]
BioMed Research International, 2016 CX3C chemokine ligand 1 (CX3CL1) is an intriguing chemokine belonging to the CX3C family. CX3CL1 is secreted by neurons and plays an important role in modulating glial activation in the central nervous system after binding to its sole receptor CX3CR1 which mainly is expressed on microglia.
Peiqing Chen +4 more
openaire +2 more sources
CX3CR1 differentiates F4/80low monocytes into pro-inflammatory F4/80high macrophages in the liver
Scientific Reports, 2018 The expression of chemokine receptor CX3CR1 is related to migration and signaling in cells of the monocyte-macrophage lineage. The precise roles of CX3CR1 in the liver have been investigated but not clearly elucidated.
Young-Sun Lee +9 more
doaj +1 more source
Arteriolar and venular remodeling are differentially regulated by bone marrow-derived cell-specific CX3CR1 and CCR2 expression. [PDF]
PLoS ONE, 2012 The chemokine receptors CCR2 and CX3CR1 are critical for the recruitment of "inflammatory" and "resident" monocytes, respectively, subpopulations that differentially affect vascular remodeling in atherosclerosis.
Joshua K Meisner +2 more
doaj +1 more source
Cx3cr1-deficient microglia exhibit a premature aging transcriptome. [PDF]
, 2019 CX3CR1, one of the highest expressed genes in microglia in mice and humans, is implicated in numerous microglial functions. However, the molecular mechanisms underlying Cx3cr1 signaling are not well understood.
Allaire, Norm +15 more
core
Experimental Eye Research, 2013 Monocytes, macrophages, dendritic cells and microglia play critical roles in the local immune response to acute and chronic tissue injury and have been implicated in the pathogenesis of age-related macular degeneration. Defects in Ccl2-Ccr2 and Cx3cl1-Cx3cr1 chemokine signalling cause enhanced accumulation of bloated subretinal microglia/macrophages in
Luhmann, Ulrich F.O. +7 more
openaire +2 more sources
Pancreatic Stellate Cells and CX3CR1 [PDF]
Pancreas, 2014 Numerous studies suggest important roles of the chemokine, fractalkine (CX3CL1), in acute/chronic pancreatitis; however, the possible mechanisms of the effects are unclear. Pancreatic stellate cells (PSCs) can play important roles in pancreatitis, secreting inflammatory cytokines/chemokines, as well as proliferation.
Masahiko, Uchida +10 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim +5 more
wiley +1 more source
Association of Cytomegalovirus DNA and Immunologic Markers of Cardiovascular Disease. [PDF]
, 2019 BackgroundPersons living with human immunodeficiency virus (HIV) (PLWH) with high cytomegalovirus (CMV)-specific interferon (IFN) γ response have increased numbers of endothelium homing receptor (CX3CR1)+-expressing cells that are associated with ...
Garg, Ankita +4 more
core
Inflammation as a Central Mechanism in Alzheimer\u27s Disease [PDF]
, 2018 Alzheimer\u27s disease (AD) is a progressive neurodegenerative disorder that is characterized by cognitive decline and the presence of two core pathologies, amyloid β plaques and neurofibrillary tangles.
Bemiller, Shane M. +5 more
core +2 more sources
Role of CX3CL1/CX3CR1 Signaling Axis Activity in Osteoporosis [PDF]
Mediators of Inflammation, 2019 Osteoporosis is a civilization disease which is still challenging for contemporary medicine in terms of treatment and prophylaxis. It results from excessive activation of the osteoclastic cell line and immune cells like macrophages and lymphocytes.
Piotr Wojdasiewicz +4 more
openaire +3 more sources