Results 41 to 50 of about 7,568 (190)

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Exploratory Evidence of a Gene–Smoking Interaction Involving MTR rs1805087 in Type 2 Diabetes Mellitus

ELECTROPHORESIS, EarlyView.
The graphical abstract illustrates how smoking interacts with an MTR rs1805087 gene variant to promote insulin resistance and β‐cell dysfunction through alterations in the folate cycle. PCR–RFLP genotyping and machine‐learning analysis support an exploratory assessment linking these combined factors to increased Type 2 diabetes risk in susceptible ...
João Pedro Costa Roriz, Leandro Prado Assunção, Nayane Soares de Lima, Diolina Gonçalves da Silva, Rodrigo da Silva Santos, Angela Adamski da Silva Reis   +5 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Optimization of Cyanocobalamin (Vitamin B₁₂) Sorption onto Mesoporous Superparamagnetic Iron Oxide Nanoparticles

Molecules
The techniques used to detect and quantify cyanocobalamin (vitamin B12) vary considerably in terms of detection sensitivity, from the most sensitive, based on radioisotopes and mass spectrometry (MS) with limits of detection (LOD) in fg mL−1, to ...
Jolanta Flieger, Natalia Żuk, Sylwia Pasieczna-Patkowska, Michał Flieger, Rafał Panek, Tomasz Klepka, Wojciech Franus   +6 more
doaj   +1 more source

Bioavailability through lactic fermentation in millet for combating hidden hunger

Food Biomacromolecules, EarlyView.
Millets are nutrient‐rich grains with considerable potential to combat hidden hunger, but the presence of anti‐nutritional factors, can restrict mineral bioavailability. Processing strategies including soaking, germination, cooking, and lactic acid fermentation can reduce the anti‐nutritional factors.
Ajina Anila Sugathan, Naziya Kadengal, Vinod Kumar Nathan, Prakash M. Halami   +3 more
wiley   +1 more source

Lack of association between serum vitamin B12 and nocturnal sleep parameters following cyanocobalamin supplementation in healthy adults

Heliyon, 2022
Background: This study examined the effect of vitamin B12 supplementation on sleep parameters of latency, total sleep time, wake-after-sleep onset, total time in bed and sleep efficiency in healthy adults.
Toshiba Channer-Wallen, Paula Dawson, Peta-Gaye Thomas-Brown, Maxine Gossell-Williams   +3 more
doaj   +1 more source

Synthesis of a “Base‐On” Yellow Corrinoid From Vitamin B12

Helvetica Chimica Acta, EarlyView.
A rare “base‐on” yellow corrinoid is obtained from vitamin B12 in a concise semi‐synthesis. Structural and spectroscopic characterization identifies 5,6‐dihydroxyaquacobalamin, in which interruption of the corrin π‐system coexists with dimethylbenzimidazole coordination to cobalt(III), providing new insight into the structure and electronic properties ...
Lucas Prieto, Christopher Brenig, Felix Zelder   +2 more
wiley   +1 more source

More than just anemia: Uncovering celiac disease beneath the surface: A case report

JPGN Reports, EarlyView.
Abstract Celiac disease (CD) is an immune‐mediated disorder triggered by gluten in genetically susceptible individuals. Although iron deficiency anemia is a common presentation, other micronutrient deficiencies may occur. We describe a 3.5‐year‐old female whose initial presentation of CD was severe, asymptomatic normocytic anemia secondary to copper ...
Evan Greenhall, Bri Best, David F. Carpenteri, Paula Prieto‐Tizzard   +3 more
wiley   +1 more source

Cyanocobalamin Ultraflexible Lipid Vesicles: Characterization and In Vitro Evaluation of Drug-Skin Depth Profiles

Pharmaceutics, 2021
Atopic dermatitis (AD) and psoriasis are the most common chronic inflammatory skin disorders, which importantly affect the quality of life of patients who suffer them.
Antonio José Guillot, Enrique Jornet-Mollá, Natalia Landsberg, Carmen Milián-Guimerá, M. Carmen Montesinos, Teresa M. Garrigues, Ana Melero   +6 more
doaj   +1 more source

Macronutrient and micronutrient profiles of meat types: insights into human health and diet

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Despite considerable advances in global health and nutrition, emerging challenges such as population growth, climate change, and limited natural resources continue to threaten food security. Meat remains an essential component of the human diet, supplying high‐quality proteins, essential amino acids, lipids, vitamins, and minerals necessary ...
Özgül Anitaş, Serap Göncü, Fatma Hepsağ, Nazan Koluman, Yesim Ozogul   +4 more
wiley   +1 more source