Results 111 to 120 of about 58,672 (259)

Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu   +9 more
wiley   +1 more source

sGC stimulator BAY 41‐8543 improves survival and ventricular function in a rat model of doxorubicin‐induced cardiomyopathy with nephrotic syndrome

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anthracyclines such as doxorubicin (DOXO) remain a cornerstone of cancer therapy but are associated with a high risk of cardiotoxicity and subsequent heart failure (HF). Impairment of NO/soluble guanylyl cyclase (sGC)/cGMP pathway has been reported in anthracycline‐induced cardiomyopathy.
Olga Gawrys   +14 more
wiley   +1 more source

Bridging the implementation gap in MCABC inventory management: from a taxonomy to practical archetypes

open access: yesInternational Transactions in Operational Research, EarlyView.
Abstract Despite increasing demands for resilient and sustainable supply chains, inventory management often relies on outdated single‐criterion analyses. While multi‐criteria ABC (MCABC) analyses provide a theoretically mature assessment of resilience‐sustainability‐benefit trade‐offs in inventory, their adoption remains limited due to fragmented ...
Lukas Grützner, Michael H. Breitner
wiley   +1 more source

Forming European Political Awareness and Facilitating Civic Engagement? Mainstream Europarties in Social Media

open access: yesJCMS: Journal of Common Market Studies, EarlyView.
Abstract This study investigates how mainstream Europarties utilise social media to communicate with the public. According to EU law, Europarties are expected to strengthen the EU's legitimacy, mainly by fostering European political awareness and facilitating civic engagement.
Stefano Greco, Tapio Raunio
wiley   +1 more source

The miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell injury in diabetic nephropathy

open access: yesJournal of Diabetes Investigation, EarlyView.
Suppression of miR‐145‐5p alleviates DN‐associated renal tissue damage by inhibiting NRF2/SLC7A11‐mediated ferroptosis of RTECs. ABSTRACT Purpose This study aimed to investigate the molecular mechanism by which the miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell (RTEC) injury in diabetic nephropathy (DN ...
Ganlin Wu   +5 more
wiley   +1 more source

Fish welfare in a changing world: New developments and current challenges

open access: yesJournal of Fish Biology, EarlyView.
Abstract The welfare of non‐human animals is central to ethical discussions on animal use, with increasing attention to fish welfare across research, aquaria, aquaculture, and fisheries. This paper reviews current theoretical approaches to animal welfare and recent advances in defining and assessing fish welfare since the seminal paper by Huntingford ...
Sonia Rey Planellas   +16 more
wiley   +1 more source

The reproducibility gap in graph neural network workflows for cell dynamics: A checklist‐driven case study

open access: yesJournal of Microscopy, EarlyView.
Abstract As part of a Global BioImage Analysts' Society (GloBIAS) initiative, we evaluated the reproducibility of a Graph Neural Network (GNN) study on cell dynamics using structured, community‐developed checklists from the Quality Assessment and Reproducibility for Instruments and Images in Light Microscopy (QUAREP‐LiMi) initiative.
Martin Schätz, Ko Sugawara
wiley   +1 more source

GloBIAS survey results – An insight into the global bioimage analysis community

open access: yesJournal of Microscopy, EarlyView.
Abstract There is a global need for bioimage analysis (BIA) as advances in life sciences increasingly rely on cutting‐edge imaging systems that have dramatically expanded the complexity and dimensionality of biological images. Turning these data into scientific discoveries requires scientists with effective data management skills and knowledge of state‐
Laura R. de la Ballina   +17 more
wiley   +1 more source

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