Results 121 to 130 of about 97,777 (282)

Management cybernetics

open access: yes, 2010
Management cybernetics is the field of cybernetics concerned with management and organizations. The notion of cybernetics and management was first introduced by Stafford Beer in the late 1950s.
Omari, Bashiru
core  

Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu   +9 more
wiley   +1 more source

sGC stimulator BAY 41‐8543 improves survival and ventricular function in a rat model of doxorubicin‐induced cardiomyopathy with nephrotic syndrome

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anthracyclines such as doxorubicin (DOXO) remain a cornerstone of cancer therapy but are associated with a high risk of cardiotoxicity and subsequent heart failure (HF). Impairment of NO/soluble guanylyl cyclase (sGC)/cGMP pathway has been reported in anthracycline‐induced cardiomyopathy.
Olga Gawrys   +14 more
wiley   +1 more source

Kininase I drives angiotensin II‐induced hypertension through activation of the bradykinin B1 receptor

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kininase I, comprising carboxypeptidase N (CPN) and carboxypeptidase M, regulates kinin activity and is up‐regulated during injury, inflammation and immune activation. Under these conditions, kininase I converts bradykinin and kallidin into des‐Arg kinins, primary endogenous agonists of the bradykinin B1 receptor (R ...
Acacia White   +5 more
wiley   +1 more source

Integrated chemical profiling, transcriptomics and functional validation elucidate the multifunctional benefits of a triple‐ferment filtrate complex for skin aging intervention

open access: yesInternational Journal of Cosmetic Science, EarlyView.
Integrated chemical profiling, transcriptomics and functional validation reveal the multifunctional benefits of a triple‐ferment filtrate complex for skin aging intervention. Abstract Objective Skin aging is driven by interconnected hallmarks including oxidative stress and chronic low‐grade inflammation, cellular senescence, impaired epidermal function
Ping Gao   +4 more
wiley   +1 more source

Usability: A Cybernetics Perspective.

open access: yes, 2020
Abstract Usability as a concept is well established, encapsulating the rich interaction between different kinds of users, information technology systems, and contexts of use. In the context of socio-technical systems, technology shapes societies and human interactions, and likewise technology itself is shaped by social, economic, and political forces ...
Rajanen Mikko, Rajanen Dorina
openaire   +2 more sources

Chronic Excessive Exercise Aggravates Apical Periodontitis in Mice

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Aim To investigate the effects of overtraining on the development of apical periodontitis (AP) in mice. Methodology Sixty 6‐week‐old male C57BL/6 mice were allocated to six groups: sedentary without AP (SED); sedentary with AP (SED AP); aerobic training without AP (AERO); aerobic training with AP (AERO AP); overtraining without AP (OVER); and ...
Andréia Bosco Boaventura   +6 more
wiley   +1 more source

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