Results 91 to 100 of about 64,381 (295)

AMPK:a target for drugs and natural products with effects on both diabetes and cancer [PDF]

, 2013
The AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy that appears to have arisen at an early stage during eukaryotic evolution.
Chen, Cool, Corton, D. G. Hardie, Davies, Davies, El-Mir, Foretz, Greer, Hardie, Hardie, Hawley, Hawley, Hawley, Hawley, Huang, Hwang, Imamura, Jaleel, Ji, Jones, Liang, Lin, Lochhead, Lowell, Miners, Mooney, Musi, Oakhill, Rothwell, Rothwell, Scott, Stahmann, Suissa, Thaler, Timmers, Vara, Vincent, Woods, Woods, Xiao, Xiao, Yang, Yin   +43 more
core   +4 more sources

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Cyclic AMP‐dependent protein kinase of yeast [PDF]

FEBS Letters, 1981
Sy, Jose, Roselle, Michael
openaire   +2 more sources

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

Crosstalk between cAMP and MAP Kinase Signaling in the Regulation of Cell Proliferation

, 2002
Hormonal stimulation of cyclic adenosine monophosphate (cAMP) and the cAMP-dependent protein kinase PKA regulates cell growth by multiple mechanisms.
Altschuler, Ambrosini, Arai, Arslan, Barberis, Barnier, Blanco-Aparicio, Bos, Boucher, Burgering, Burgun, Busca, Caron, Cass, Chen, Chen, Chen, Cheng, Chiloeches, Ciullo, Cole, Cook, Cook, Cospedal, Crepieux, Crespo, Crespo, D'Angelo, Daaka, de Rooij, Deeble, Depoortere, Dhillon, Dremier, Dugan, Feliciello, Filippa, Gonzalez-Robayna, Gottesman, Graves, Greenberg, Grewal, Grewal, Howe, Hsueh, Hu, Iacovelli, Iida, Kahan, Kao, Katagiri, Kato, Kawasaki, Kievit, Kim, Kitayama, Kobierski, Kubicek, L'Allemain, LaBaer, Lee, Lindquist, MacNicol, Mason, McKenzie, Mei, Mikula, Mischak, Misra-Press, Morice, Mutoh, Myklebust, Naderi, Ohba, Osinski, Patterson, Pham, Piiper, Plevin, Qiu, Quilliam, Reedquist, Ribeiro-Neto, Richards, Rommel, Saxena, Schmitt, Schmitt, Schmitt, Scott, Sebzda, Seger, Sevetson, Sidovar, Swanson, Thoresen, Thorson, Tsukamoto, Tsygankova, Tsygankova, Vaillancourt, van Oirschot, Verheijen, Vogt Weisenhorn, von Lintig, Vossler, Wan, Wang, Wellbrock, Wojnowski, Wu, Yamaguchi, Yarwood, Yee, Yonehara, York, Young, Zanassi, Zhang, Zimmermann, Zou, Zwartkruis, Zwartkruis   +122 more
core   +1 more source

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core   +2 more sources

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

An evolutionary perspective on the kinome of malaria parasites [PDF]

, 2012
Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL ...
Andrew B. Tobin, Carvalho T. G., Christian Doerig, Eric Talevich, Natarajan Kannan, Wells T. N., Wilson R. J.   +6 more
core   +1 more source

Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells

Advanced Science, EarlyView.
This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu, Zihui Zheng, Wang Li, Chenyi Shou, Ying Zhao, Lijun Zhang, Xiaoli Shi, Yunfeng Hu, Huanhuan Zhao, Huiwen Wu, Jun Guo   +10 more
wiley   +1 more source

A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. [PDF]

, 2015
The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute
Ahmadian, Maryam, Chang, Louise, Downes, Michael, Evans, Ronald M, Korytnaya, Evgenia, Krause, Danielle M, Liddle, Christopher, Lumeng, Carey N, Neidert, Adam, Oral, Elif A, Peng, Xiaoling, Poirier, BreAnne, Reilly, Shannon M, Saltiel, Alan R, Uhm, Maeran, Yu, Ruth T, Zamarron, Brian F   +16 more
core   +2 more sources