Results 151 to 160 of about 87,778 (377)
Mari K. Haddox +2 more
semanticscholar +1 more source
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis +9 more
wiley +1 more source
Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy [PDF]
Tuberculosis (TB) is an ancient disease remaining a serious health threat worldwide. It is caused by Mycobacterium tuberculosis (Mtb), an acid-fast bacilli, non-sporulated, slow-growing, immobile and aerobic.
Colombo, Maria Isabel +2 more
core
Aims Vutiglabridin (HSG4112) is a novel drug under clinical development for antiobesity treatment. This study aimed to evaluate the pharmacokinetics (PKs) and safety of vutiglabridin after multiple oral administrations in healthy Korean female and obese subjects and explore short‐term pharmacodynamic (PD) responses.
Sooyoun Lee +5 more
wiley +1 more source
Effects of [D-Ala1] Peptide T-NH2 and HIV Envelope Glycoprotein Gp120 on Cyclic AMP Dependent Protein Kinases in Normal and Psoriatic Human Fibroblasts [PDF]
Charis Liapi +4 more
openalex +1 more source
Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma +9 more
wiley +1 more source
To enhance nylon waste remediation, genome mining was used to identify a thermostable laurolactam hydrolase from Thermopolyspora flexuosa with activity against an important cyclic nylon derivative. Substrate scope analysis and structural modeling revealed key features controlling enzyme‐substrate compatibility, providing a promising foundation for ...
Maria E. Cleveland +3 more
wiley +1 more source

