Results 241 to 250 of about 87,184 (381)

Alpha‐Ketoglutarate Ameliorates Synaptic Plasticity Deficits in APP/PS1 Mice Model of Alzheimer's Disease

Aging Cell, EarlyView.
This schematic illustration summarizes the effects of calcium alpha‐ketoglutarate (CaAKG) on synaptic plasticity in a mouse model of Alzheimer's disease (APP/PS1). CaAKG enhances autophagy and restores LTP in APP/PS1 mice via NMDAR‐independent, LTCC, and CPAMPAR‐dependent pathways.
Sheeja Navakkode, Brian K. Kennedy
wiley   +1 more source

PM_2.5 affected ciliary beat frequency of axonemes via the cyclic AMP-dependent protein kinase a pathway. [PDF]

Front Public Health
Pang J, Xiong Z, Zhang K, Li Y.
europepmc   +1 more source

Role of 3':5'-cyclic-AMP-dependent protein kinase in regulation of protein synthesis in reticulocyte lysates.

Proceedings of the National Academy of Sciences of the United States of America, 1977
A. Datta, C. de Haro, J. M. Sierra, S. Ochoa   +3 more
semanticscholar   +1 more source

Mitigating Pro‐Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy

Aging Cell, EarlyView.
Senescent cells accumulate extranuclear DNA fragments that are recognized by the cyclic GMP‐AMP synthase (cGAS) and its effector protein stimulator of interferon genes (STING), which promotes expression of SASP and DAMP genes by inducing nuclear factor‐kappa B (NF‐κB) and IFN regulatory factor 3 (IRF3) translocation.
Anna Barkovskaya, Ashley Brauning, Aditi Thambala, Kriti Bhardwaj, Manish Chamoli, Anand Rane, Julie K. Andersen, Amit Sharma   +7 more
wiley   +1 more source

Interferon signaling and STING pathway in head and neck cancers: unlocking immune secrets and therapeutic frontiers. [PDF]

Cancer Cell Int
Zolfaghari K, Yazdi M, Mohammadioun S, Tajafrooz F, Malekfarnood H, Saleki K, Rezaei N.   +6 more
europepmc   +1 more source

Phosphorylation of the glycogen‐binding subunit of protein phosphatase‐1_G by cyclic‐AMP‐dependent protein kinase promotes translocation of the phosphatase from glycogen to cytosol in rabbit skeletal muscle

, 1986
Akira Hiraga, Philip Cohen
openalex   +1 more source

Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells [PDF]

, 1991

openalex   +1 more source

A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells.

Proceedings of the National Academy of Sciences of the United States of America, 1975
J. Hochman, P. Insel, H. Bourne, P. Coffino, G. Tomkins   +4 more
semanticscholar   +1 more source

Enhancing Late‐Life Survival and Mobility via Mitohormesis by Reducing Mitochondrial Calcium Levels

Aging Cell, EarlyView.
RNAi knockdown (KD) of mcu‐1 or mitoxantrone treatment lowers mitochondrial Ca2+, extends lifespan, and preserves motility during aging. Benefits require early intervention and involve a transient ROS increase that activates a pmk‐1, daf‐16, and skn‐1 pathway, enhancing stress defense and mitochondrial integrity while reducing early‐life survival ...
Doruntina Bresilla, Ines Tawfik, Martin Hirtl, Sonja Gabrijelčič, Julian Ostaku, Fabienne Mossegger, Lia Wurzer, Susanne Lederer, Katarina Kalinova, Ernst Malle, Markus Schosserer, Kim Zarse, Michael Ristow, Corina T. Madreiter‐Sokolowski   +13 more
wiley   +1 more source

The role of AMPK signaling pathway in the pathogenesis of type 2 diabetes mellitus with its complications and related metabolic disorders. [PDF]

Metabol Open
Hunie Tesfa K, Desalegn Gebeyehu C, Tadele Ewunetie A, Gugsa E, Nigatu Zewdie A, Dessie G, Tezera Endale H.   +6 more
europepmc   +1 more source