Results 251 to 260 of about 87,184 (381)

HSPA12B Protects Against Age‐Related Endothelial Cell Senescence by Regulating STING Degradation

Aging Cell, EarlyView.
Activation of the cGAS–STING pathway contributes to age‐related cardiac endothelial senescence, fibrotic remodeling, and functional decline. HSPA12B preserves endothelial homeostasis during aging by promoting XBP1‐dependent, SEL1L/HRD1‐mediated endoplasmic reticulum–associated degradation of STING, thereby attenuating cardiac endothelial senescence ...
Tingting Li, Peilin Zhu, Joseph Adams, Fei Tu, Jialing Wang, Chloe Garbe, Suman Dalal, Krishna Singh, Xiaojin Zhang, Li Liu, David L. Williams, Chuanfu Li, Xiaohui Wang   +12 more
wiley   +1 more source

Extending protein-film electrochemistry across enzymology and biological inorganic chemistry to investigate, track and control the reactions of non-redox enzymes and spectroscopically silent metals. [PDF]

J Biol Inorg Chem
Megarity CF, Herold RA, Armstrong FA.
europepmc   +1 more source

Affinity purification of newly phosphorylated protein molecules. Thiophosphorylation and recovery of histones H1, H2B, and H3 and the high mobility group protein HMG-1 using adenosine 5'-O-(3-thiotriphosphate) and cyclic AMP-dependent protein kinase.

, 1980
I.Y. Sun, E. Marshall Johnson, V. G. Allfrey   +2 more
openalex   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Active Endothelial Inactivation of Hyperpermeability: The Role of Nitric Oxide-Driven cAMP/Epac1 Signaling. [PDF]

J Cardiovasc Dev Dis
Lillo MA, Burboa PC, Durán WN.
europepmc   +1 more source

Cyclic AMP-dependent protein kinase in canine pancreatic rough endoplasmic reticulum

, 1989
Sanjay K. Nigám, G Blobel
openalex   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

STING and Nonnecroptotic MLKL-Mediated Mechanisms Improve Dendritic Cell Maturation and Killing of Cancer Cells. [PDF]

Eur J Immunol
Jensen TS, Laursen MF, Schort L, Banasik AJ, Agger R, Jakobsen MR, Kofod-Olsen E.   +6 more
europepmc   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Regulation of antiviral and antimicrobial innate immunity and immune evasion. [PDF]

Cell Mol Life Sci
Wang L, He D, Satoh-Takayama N, Zheng C, Xing J.   +4 more
europepmc   +1 more source