Results 251 to 260 of about 87,778 (377)

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

The cyclic peptide mallotumide A inhibits colon and breast cancer cell growth and motility by targeting cellular respiration and lipogenesis. [PDF]

Sci Rep
Laowittawat C, Sawektreeratana N, Katewongsa K, Payomhom P, Hongthong S, Reutrakul V, Kuhakarn C, Jitrapakdee S.   +7 more
europepmc   +1 more source

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

, 1990
Takashi Chijiwa, Akihiko Mishima, Masatoshi Hagiwara, Mamoru Sano, Kensuke Hayashi, Tomoyuki Inoue, K. Naito, T. TOSHIOKA, Hisashi Hidaka   +8 more
openalex   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, EarlyView.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

Activation of cGAS-STING signaling in senescent cells promotes the aging process by remodeling the functions of the immune system. [PDF]

Biogerontology
Salminen A, Kaarniranta K, Kauppinen A.
europepmc   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Impact of MEK inhibition on T-cell infiltration and function after radiotherapy in KRAS-mutant lung cancer. [PDF]

Front Immunol
Zheng Y, Su C, Pan J, Wang Y, Zhao M, Zhang M, Yan P, Liu N, Sun M.   +8 more
europepmc   +1 more source

Faculty Opinions recommendation of Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes.

, 2008
Silvana Curci, Andrea Gerbino
openalex   +2 more sources

Prognostic Biomarker of Fertility‐Preserving Hormonal Therapy Based on Multigene Panel Testing for Endometrial Cancer

Cancer Science, EarlyView.
We identified prognostic biomarkers that predict treatment outcomes in patients receiving fertility‐preserving high‐dose medroxyprogesterone acetate (MPA) therapy through comprehensive multigene panel testing. ABSTRACT In this study, we identified prognostic biomarkers that predict treatment outcome in patients receiving fertility‐preserving high‐dose ...
Takuro Hirano, Kensuke Sakai, Takuma Yoshimura, Tatsuyuki Chiyoda, Kohei Nakamura, Eriko Aimono, Miho Kawaida, Hiroshi Nishihara, Nobuyuki Susumu, Daisuke Aoki, Wataru Yamagami   +10 more
wiley   +1 more source

Crustacean Protein Kinases A and C: Bioinformatic Characterization in Decapods and Other Non-Model Organisms. [PDF]

Int J Mol Sci
Head TB, Pérez-Moreno JL, Antizzo LE, Durica DS, Mykles DL.   +4 more
europepmc   +1 more source