Results 281 to 290 of about 87,778 (377)

Studies of mice with cyclic AMP-dependent protein kinase (PKA) defects reveal the critical role of PKA’s catalytic subunits in anxiety

, 2016
George Briassoulis, Margaret F. Keil, Bilal Naved, Sophie Liu, Matthew F. Starost, Maria Nesterova, Nirmal Gokarn, Anna Batistatos, T. John Wu, Constantine A. Stratakis   +9 more
openalex   +1 more source

Haploinsufficiency of brain‐specific kinase BRSK1 causes epilepsy and neurodevelopmental disorders

Epilepsia, EarlyView.
Abstract Objective The BRSK1 gene encodes brain‐specific serine/threonine kinase 1 (also known as SAD‐B kinase), which is almost exclusively expressed in the brain and plays critical roles in neuronal polarization, neurotransmitter release, mitochondrial dynamics, and neuronal maturation.
Qi Zhang, Hiroshi Yamanaka, Ping Li, Yingfeng Li, Tian Luo, Miao Xia, Ting Liu, Xueyan Liu, Qing Lu, Bin Yang, Fan He, Kaixian Du, Yousheng Shu, Bo Peng, Yong‐hui Jiang, Yi Wang   +15 more
wiley   +1 more source

Interferon-Based Therapeutics in Cancer Therapy: Past, Present, and Future. [PDF]

Int J Mol Sci
Vorona K, Ryapolova A, Sokolova O, Karabelsky A, Ivanov R, Reshetnikov V, Minskaia E.   +6 more
europepmc   +1 more source

Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine

Equine Veterinary Education, EarlyView.
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell, J. Brandly, W. W. Muir III, J. Page, K. Hopster   +4 more
wiley   +1 more source

Recharging the Powerhouse: Mitochondrial Dysfunction and Therapy in Cardiorenal Syndrome Type 4. [PDF]

Curr Heart Fail Rep
Long E, Heihre JM.
europepmc   +1 more source

Propionibacterium acnes evades microbicidal phagocytosis by inhibiting the mitochondrial biogenesis of nucleus pulposus cells

The FEBS Journal, EarlyView.
P. acnes infection impairs the mitochondrial biogenesis of nucleus pulposus cells (NPCs) through the AMPK/SIRT‐1/PGC‐1α signaling pathway. This results in impaired mitochondria that are unable to generate sufficient ATP, and impaired delivery of mitochondrial reactive oxygen species to carry out the bactericidal process effectively.
Lemeng Ren, Changwei Li, Juntao Sun, Yuehuan Zheng, Yucheng Jiao, Jiancheng Zheng, Fangke Zhang, Yazhou Lin, Wenjian Wu, Peng Cao   +9 more
wiley   +1 more source

Extending protein-film electrochemistry across enzymology and biological inorganic chemistry to investigate, track and control the reactions of non-redox enzymes and spectroscopically silent metals. [PDF]

J Biol Inorg Chem
Megarity CF, Herold RA, Armstrong FA.
europepmc   +1 more source

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, EarlyView.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Activity of protein kinase C controls the efficacy of cannabinoid receptor type 1 in the medial prefrontal cortex after neuropathic pain. [PDF]

J Neurophysiol
Chao D, Liu Y, Cheng T, Hogan QH, Pan B.
europepmc   +1 more source

Studies of the mechanism of antidiuretic hormone release [PDF]

, 1977
Dahl, G., Gratzl, Manfred, Moses, A. M., Russell, J. T., Thorn, N. A.   +4 more
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