Results 291 to 300 of about 87,184 (381)

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Diabetes management in maternally inherited diabetes and deafness (MIDD): A review and a proposed treatment algorithm

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Maternally inherited diabetes and deafness (MIDD) is a mitochondrial disorder usually caused by the variant m.3243A>G in the MT‐TL1 gene. We have proposed that diabetes in MIDD arises from a combination of insulin resistance and impaired β‐cell function that is more likely to occur in the presence of high skeletal muscle heteroplasmy and ...
Ahsen Chaudhry, David M. Thompson, Jean‐Pierre Chanoine   +2 more
wiley   +1 more source

Dioscin from smilax china rhizomes inhibits platelet activation and thrombus formation via up-regulating cyclic nucleotides. [PDF]

Sci Rep
Lee GH, Lee JP, Heo NY, Lee CD, Kim G, Wahab AA, Rhee MH, Lee S, Lee DH.   +8 more
europepmc   +1 more source

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source

Adenosine and adenosine receptors: a "double-edged sword" in cardiovascular system. [PDF]

Front Pharmacol
Qian Y, Zheng Y, Leng L, Liu Q, Tian X, Chen S, Zhang S, Xie J.   +7 more
europepmc   +1 more source

Epithelial cell shape changes contribute to regulation of ureteric bud branching morphogenesis

The FEBS Journal, EarlyView.
Ureteric bud (UB) branching determines the final size, shape, and nephron number of kidneys. Characterization of UB cell shapes identified dynamic round‐to‐elliptical transitions and cellular volume changes as critical epithelial modifications that increase morphological complexity in UB tips during their transitions through ampulla‐to‐asymmetric ...
Kristen Kurtzeborn, Vladislav Iaroshenko, Tomáš Zárybnický, Julia Koivula, Heidi Anttonen, Otto J. M. Mäkelä, Darren Bridgewater, Ramaswamy Krishnan, Ping Chen, Satu Kuure   +9 more
wiley   +1 more source

Tumor irradiation induced immunogenic response: the impact of DNA damage induction and misrepair. [PDF]

Radiat Oncol
Liu Q, Shi X, Tayier N, Ma L.
europepmc   +1 more source

Posttranslational modifications of phosphodiesterase type 4 enzymes represent novel points for therapeutic targeting

The FEBS Journal, EarlyView.
Enzymes from the phosphodiesterase type 4 family (PDE4) coordinate physiological events driven by the cyclic AMP s(cAMP) signaling pathway by tightly controlling cAMP dynamics in many cell types. Key to this strict regulation is the myriad of posttranslational modifications that alter PDE4 activity, cellular location, and binding partner selection ...
Madihah Hussain, Gonzalo S. Tejeda, George S. Baillie   +2 more
wiley   +1 more source

Cdk activation by phosphorylation: linking growth signals to cell cycle control. [PDF]

Biochem Soc Trans
Blank HM, No EG, Polymenis M.
europepmc   +1 more source

Gasdermins: multifunctional effectors of membrane permeabilization across cellular compartments

The FEBS Journal, EarlyView.
Gasdermins (GSDMs) are pore‐forming proteins best known for driving pyroptosis through plasma membrane (PM) permeabilization. Beyond triggering inflammatory cell death, GSDMs can also associate with organelle membranes, including mitochondria, lysosomes, ER, and nucleus, where they modulate membrane integrity and cellular signaling.
Eleonora Margheritis, Nadine Gehle, Katia Cosentino   +2 more
wiley   +1 more source