Results 311 to 320 of about 87,778 (377)
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Cyclic AMP-dependent protein kinase of Neurosporacrassa
Biochemical and Biophysical Research Communications, 1980Abstract Neurospora crassa was surveyed for cyclic AMP-dependent protein kinase activity. Two peaks (I and II) of protein kinase activity were demonstrated by DEAE-cellulose chromatography of wild type Neurospora extracts. Peak I was stimulated by cyclic AMP, eluted below 60 mM NaCl and had high activity using histone H2B as substrate ...
P A, Powers, M L, Pall
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Phosphorylation of Tau by Cyclic-AMP-Dependent Protein Kinase
Dementia and Geriatric Cognitive Disorders, 1993Alzheimer's disease paired helical filaments contain abnormally phosphorylated tau (PHF-tau) which has reduced electrophoretic mobility on sodium dodecyl sulphate polyacrylamide electrophoresis. We have investigated the effects of cyclic-AMP-dependent protein kinase (PKA) on recombinant human tau isoforms and two recombinant tau fragments.
J, Robertson +6 more
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Activation of cyclic AMP-dependent protein kinase in macrophages
Biochemical and Biophysical Research Communications, 1984The activity of cyclic AMP-dependent protein kinase (cyclic AMP-PK) was significantly higher (P less than 0.001) in thioglycollate-elicited than in resident rat peritoneal macrophages. The activity ratio of the enzyme (its activity in the absence of added cyclic AMP divided by that in the presence of 5 microM cyclic AMP) was similar in the two cell ...
N H, Hunt +4 more
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[41] Assay of cyclic AMP-dependent protein kinases
Methods in Enzymology, 1974Jackie D. Corbin, Erwin M. Reimann
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Inhibition of cyclic AMP-dependent protein kinase by curcumin
Phytochemistry, 1996Curcumin [diferuloylmethane; 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione], a major bioactive secondary metabolite found in the rhizomes of turmeric (Curcuma longa), is an inhibitor of Ca(2+)- and phospholipid-dependent protein kinase C (PKC) and of the catalytic subunit (cAK) of cyclic AMP-dependent protein kinase (IC50 values 15 and 4 ...
M, Hasmeda, G M, Polya
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Protein Phosphorylation Catalyzed by Cyclic AMP-Dependent and Cyclic GMP-Dependent Protein Kinases
Annual Review of Pharmacology and Toxicology, 1980D B, Glass, E G, Krebs
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Effect of indomethacin on the cyclic AMP-dependent protein kinase
European Journal of Pharmacology, 1980Indomethacin inhibited cyclic AMP-dependent protein kinase activity in small intestine in in vivo experiments. An inverse pattern of variation was exhibited by acetyl salicylic acid, eterylate and benorylate, acetyl-p-amino-phenol being inactive. Indomethacin, acetyl salicylic acid, eterylate and benorylate increased the protein kinase activity in ...
R E, Catalán +4 more
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Phosphorylation of casein by cyclic AMP-dependent protein kinase
Biochemical and Biophysical Research Communications, 1977Abstract The catalytic subunit of rabbit muscle cyclic AMP-dependent protein kinase (EC 2.7.1.37; ATP:protein transferase) has been tested on a variety of caseins. The B variant of β-casein was phosphorylated at a much greater rate than other β-caseins, αs1-caseins, and κ-caseins. Whole casein homozygous for β-casein B was phosphorylated at 2.5 times
E W, Bingham +2 more
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Cisplatin resistance in cyclic AMP-dependent protein kinase mutants
Pharmacology & Therapeutics, 1998The emergence of cisplatin resistance poses a major problem to the successful treatment of a variety of human malignancies. Therefore, understanding the molecular mechanisms that underlie cisplatin resistance could significantly improve the clinical efficacy of this cytotoxic agent.
M E, Cvijic, W L, Yang, K V, Chin
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Cyclic AMP-dependent protein kinase phosphorylates serine378 in vitronectin
Biochemical and Biophysical Research Communications, 1991We previously observed that Ser378 in the heparin-binding domain of vitronectin becomes phosphorylated by a protein kinase in plasma upon addition of ATP and divalent cations. We now report that purified plasma vitronectin contains approximately 2.5 mol of phosphate per mol of protein and that vitronectin becomes phosphorylated during biosynthesis in ...
J H, Mehringer +2 more
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