Results 321 to 330 of about 87,184 (381)
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Cyclic AMP-dependent protein kinase of Neurosporacrassa
Biochemical and Biophysical Research Communications, 1980Abstract Neurospora crassa was surveyed for cyclic AMP-dependent protein kinase activity. Two peaks (I and II) of protein kinase activity were demonstrated by DEAE-cellulose chromatography of wild type Neurospora extracts. Peak I was stimulated by cyclic AMP, eluted below 60 mM NaCl and had high activity using histone H2B as substrate ...
Patricia A. Powers, Martin L. Pall
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Phosphorylation of Tau by Cyclic-AMP-Dependent Protein Kinase
Dementia and Geriatric Cognitive Disorders, 1993Alzheimer's disease paired helical filaments contain abnormally phosphorylated tau (PHF-tau) which has reduced electrophoretic mobility on sodium dodecyl sulphate polyacrylamide electrophoresis. We have investigated the effects of cyclic-AMP-dependent protein kinase (PKA) on recombinant human tau isoforms and two recombinant tau fragments.
Kenneth J. Murray +6 more
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Inhibition of cyclic AMP-dependent protein kinase by curcumin
Phytochemistry, 1996Curcumin [diferuloylmethane; 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione], a major bioactive secondary metabolite found in the rhizomes of turmeric (Curcuma longa), is an inhibitor of Ca(2+)- and phospholipid-dependent protein kinase C (PKC) and of the catalytic subunit (cAK) of cyclic AMP-dependent protein kinase (IC50 values 15 and 4 ...
Mery Hasmeda, Gideon M. Polya
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Activation of cyclic AMP-dependent protein kinase in macrophages
Biochemical and Biophysical Research Communications, 1984The activity of cyclic AMP-dependent protein kinase (cyclic AMP-PK) was significantly higher (P less than 0.001) in thioglycollate-elicited than in resident rat peritoneal macrophages. The activity ratio of the enzyme (its activity in the absence of added cyclic AMP divided by that in the presence of 5 microM cyclic AMP) was similar in the two cell ...
R.D. Eichner +4 more
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Effect of indomethacin on the cyclic AMP-dependent protein kinase
European Journal of Pharmacology, 1980Indomethacin inhibited cyclic AMP-dependent protein kinase activity in small intestine in in vivo experiments. An inverse pattern of variation was exhibited by acetyl salicylic acid, eterylate and benorylate, acetyl-p-amino-phenol being inactive. Indomethacin, acetyl salicylic acid, eterylate and benorylate increased the protein kinase activity in ...
Manuel Armijo +4 more
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Phosphorylation of casein by cyclic AMP-dependent protein kinase
Biochemical and Biophysical Research Communications, 1977Abstract The catalytic subunit of rabbit muscle cyclic AMP-dependent protein kinase (EC 2.7.1.37; ATP:protein transferase) has been tested on a variety of caseins. The B variant of β-casein was phosphorylated at a much greater rate than other β-caseins, αs1-caseins, and κ-caseins. Whole casein homozygous for β-casein B was phosphorylated at 2.5 times
Elizabeth W. Bingham +2 more
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Inhibition of cyclic AMP dependent protein kinase by vanadyl sulfate [PDF]
JBIC Journal of Biological Inorganic Chemistry, 2006 Vanadium salts influence the activities of a number of mammalian enzymes in vitro but the mechanisms by which low concentrations of vanadium ameliorate the effects of diabetes in vivo remain poorly understood. The hypothesis that vanadium compounds act by inhibiting protein tyrosine phosphatases has attracted most support.
Kioumars A. Jelveh +2 more
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Protein phosphorylation catalyzed by cyclic AMP-dependent and cyclic GMP-dependent protein kinases.
Annual Review of Pharmacology and Toxicology, 1980D. Glass, E. Krebs
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Cisplatin resistance in cyclic AMP-dependent protein kinase mutants
Pharmacology & Therapeutics, 1998The emergence of cisplatin resistance poses a major problem to the successful treatment of a variety of human malignancies. Therefore, understanding the molecular mechanisms that underlie cisplatin resistance could significantly improve the clinical efficacy of this cytotoxic agent.
Mary Ellen Cvijic +2 more
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Effect of cyclic AMP-dependent protein kinases on gene expression
Advances in Enzyme Regulation, 1982Mechanisms for regulating activation of cyclic AMP-dependent protein kinase were investigated and a possible biological role of this enzyme was elucidated. Autophosphorylation of cyclic AMP-dependent protein kinase was shown to occur via an intramolecular mechanism: the regulatory subunit undergoes phosphorylation only within the holoenzyme.
M.V. Nesterova, Evgenii S. Severin
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