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An unusual cyclic AMP-dependent protein kinase from nematodes

Biochemical and Biophysical Research Communications, 1984
The search for an unusual cyclic nucleotide-dependent protein kinase in nematodes represented an attempt to gain some insight into the proposed homology of the cAMP and cGMP-dependent protein kinases. Two species of protein kinase were found in high speed supernatants of the mycophagous nematode Aphelenchus avenae.
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Cyclic AMP, cyclic AMP-dependent protein kinase, and the regulation of gene expression

Life Sciences, 1977
Abstract Biological responses produced by cAMP in mammalian cells are remarkably diverse and differ profoundly from one cell type and tissue to another. However, it is thought at this time that all effects of cAMP are mediated through the activation of cAMP-dependent protein kinases.
Diane Haddock Russell   +1 more
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Cyclic AMP-Dependent Activation of Protein Kinases in the Myocardium

1981
Upon catecholamine stimulation of the heart, the cyclic AMP-dependent activation of protein kinases appears to play an important role in the enhancement of contractility and glycogenolysis presumably by promoting the phosphorylation of myocardial proteins.
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Cyclic AMP-dependent protein kinase content of murine T and B lymphocytes

International Journal of Immunopharmacology, 1980
Murine splenic lymphocytes have been separated by non-activating procedures into enriched T and B cell populations. Cyclic AMP-dependent protein kinase (cAPK) activity has been measured in those separated cell types by histone phosphorylation. As in other tissues, lymphocyte cAPK activity was found to be predominantly a soluble enzyme.
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Phosphorylation of cardiac regulatory proteins by cyclic AMP-dependent protein kinase

American Journal of Physiology-Legacy Content, 1976
Cardiac myofibrils were purified from canine myocardium, and the regulatory proteins (troponin + tropomyosin) were extracted and shown to contain endogenous cyclic AMP-dependent protein kinase activity. Other cyclic nucleotide stimulated the protein kinase activity but only at higher concentrations.
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