Results 61 to 70 of about 78,943 (213)
Proceedings of the National Academy of Sciences of the United States of America, 1991 Three separate processes may contribute to rapid beta-adrenergic receptor desensitization: functional uncoupling from the stimulatory guanine nucleotide-binding protein Gs, mediated by phosphorylation of the receptors by two distinct kinases, the ...
N. S. Roth +4 more
semanticscholar +1 more source
A Model of the Roles of Essential Kinases in the Induction and Expression of Late Long-Term Potentiation [PDF]
, 2006 The induction of late long-term potentiation (L-LTP) involves complex interactions among second messenger cascades. To gain insights into these interactions, a mathematical model was developed for L-LTP induction in the CA1 region of the hippocampus. The differential equation-based model represents actions of protein kinase A (PKA), MAP kinase (MAPK ...
arxiv +1 more source
Biochemical Journal, 1980 Phosphorylation of eukaryotic ribosomal proteins in vitro by essentially homogeneous preparations of cyclic AMP-dependent protein kinase catalytic subunit and cyclic GMP-dependent protein kinase was compared.
O. Issinger +4 more
semanticscholar +1 more source
Journal of Pharmacological Sciences, 2006 .: Recent studies have demonstrated that activation of enzymes can be observed in living cells in response to stimulation with neurotransmitters, hormones, growth factors, and so forth.
Eishichi Miyamoto
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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
Cell Reports, 2020 Summary: Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimmune or autoinflammatory disease.
Katherine R. Balka +15 more
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Proceedings of the National Academy of Sciences of the United States of America, 1977 The initiation inhibitor of reticulocyte lysates has been shown by others to be associated with a 3':5'-cyclic-AMP-independent protein kinase that catalyzes the phosphorylation of the small (38,000 daltons) subunit of the polypeptide chain initiation ...
A. Datta +3 more
semanticscholar +1 more source
Empowering AlphaFold2 for protein conformation selective drug discovery with AlphaFold2-RAVE [PDF]
Small molecule drug design hinges on obtaining co-crystallized ligand-protein structures. Despite AlphaFold2's strides in protein native structure prediction, its focus on apo structures overlooks ligands and associated holo structures. Moreover, designing selective drugs often benefits from the targeting of diverse metastable conformations. Therefore,
arxiv +1 more source
Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation [PDF]
arXiv, 2020 How can memories be maintained from days to a lifetime, given turnover of proteins that underlie expression of long-term synaptic potentiation (LTP)? One likely solution relies on synaptic positive feedback loops, prominently including persistent activation of CaM kinase II (CaMKII) and self-activated synthesis of protein kinase M zeta (PKM).
arxiv
Proceedings of the National Academy of Sciences of the United States of America, 1975 Compared to the wild-type parental line of S49 mouse lymphoma cells, intact cells of a mutant line (kin.A) are 10-fold less sensititive to biologic effects of exogenous cyclic adenosine 3':5'-monophophosphate (cAMP), such as induction of cAMP ...
J. Hochman +4 more
semanticscholar +1 more source
Journal of Pharmacological Sciences, 2004 To clarify heterologous regulation of a receptor is important in considering medication. Histamine constricts the airway smooth muscle through the action to the H1 receptor (H1R), which contributes to asthma.
Nozomi Kawakami +3 more
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