Results 81 to 90 of about 514,078 (293)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Synthesis of medium-ring lactones via tandem methylenation/Claisen rearrangement of cyclic carbonates

, 2000
Tandem methylenation/Claisen rearrangement of cyclic carbonates derived from vinyl-substituted 1,3- and 1,4-diols afforded eight and nine-membered unsaturated lactones ...
Edward A. Anderson, Collins, I, Wilm Buhr, Davidson, JEP, James E. P. Davidson, O'Sullivan, PT, Ian Collins, Anderson, Edward, Buhr, W, Holmes, AB, Andrew B. Holmes, Richard H. Green, Justin R. Harrison, Harrison, JR, Paul T. O’Sullivan, Green, RH   +15 more
core   +1 more source

New Trends in the Conversion of CO2 to Cyclic Carbonates

, 2020
This work concerns recent advances (mainly in the last five years) in the challenging conversion of carbon dioxide (CO2) into fine chemicals, in particular to cyclic carbonates, as a meaningful measure to reduce CO2 emissions in the atmosphere and ...
Ana Ribeiro, Erivaldo Lopes, Luísa Martins   +2 more
core   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Novel β-amino-7-membered carbonates: ring-opening polymerization and copolymers with l-lactide, ε-caprolactone and trimethylene carbonate

e-Polymers
Novel seven-membered cyclic carbonates bearing β-amino-protecting groups (Cbz, Boc) were synthesized from aspartic acid. Their homopolymerization and copolymerization with l-lactide (l-LA), ε-caprolactone (ε-CL), and trimethylene carbonate (TMC) were ...
Serova Valeriia, Mankaev Badma, Agaeva Milana, Chernikova Elena, Berkovich Anna, Alekseyev Roman, Khvostov Aleksei, Timofeev Sergey, Karlov Sergey   +8 more
doaj   +1 more source

Understanding the mechanism of Pd-catalyzed allylic substitution of the cyclic difluorinated carbonates

Beilstein Journal of Organic Chemistry, 2008
We present a mechanistic investigation of Pd-catalyzed allylic substitution of cyclic gem-difluorinated carbonates 1 and 4, previously employed in the synthesis of 3',3'-difluoro-2'-hydroxymethyl-4',5'-unsaturated carbocyclic nucleosides in 17 steps. The
Jun Xu, Xiao-Long Qiu, Feng-Ling Qing
doaj   +1 more source

Cyclic Carbonates as Green Alternative Solvents for the Heck Reaction

, 2016
Organic cyclic carbonates (ethylene and propylene carbonate) are shown to be viable greener solvents for use in Heck reactions, offering a highly effective alternative to traditionally used dipolar aprotic solvents such as NMP, DMF, and ...
James Sherwood (1783390), Andrew J. Hunt (516657), Helen L. Parker (1783387), James H. Clark (22037)   +3 more
core   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Preparation of hierarchical mesoporous organic polymer for efficient synthesis of cyclic carbonates from flue gas

, 2017
Preparation of hierarchical mesoporous organic polymer for efficient synthesis of cyclic carbonates from flue ...
杨启华
core  

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source