Results 51 to 60 of about 159,782 (296)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Cyclic LRC Codes, binary LRC codes, and upper bounds on the distance of cyclic codes

, 2016
We consider linear cyclic codes with the locality property, or locally recoverable codes (LRC codes). A family of LRC codes that generalize the classical construction of Reed-Solomon codes was constructed in a recent paper by I. Tamo and A.
Barg, Alexander, Calderbank, Robert, Goparaju, Sreechakra, Tamo, Itzhak   +3 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Finding Cliques in Projective Space: A Method for Construction of Cyclic Grassmannian Codes

IEEE Access, 2020
In general, the construction of subspace codes or, in particular, cyclic Grassmannian codes in some projective space Pq(n) is highly mathematical and requires substantial computational power for the resulting searches.
Ismael Gutierrez-Garcia, Ivan Molina Naizir   +1 more
doaj   +1 more source

Optimal Linear and Cyclic Locally Repairable Codes over Small Fields

, 2015
We consider locally repairable codes over small fields and propose constructions of optimal cyclic and linear codes in terms of the dimension for a given distance and length.
Yaakobi, Eitan, Zeh, Alexander
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A Note on Cyclic Codes from APN Functions

, 2013
Cyclic codes, as linear block error-correcting codes in coding theory, play a vital role and have wide applications. Ding in \cite{D} constructed a number of classes of cyclic codes from almost perfect nonlinear (APN) functions and planar functions over ...
Qi, Yanfeng, Tang, Chunming, Xu, Maozhi
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Repeated-Root Constacyclic Codes Over the Chain Ring F_p^m[u]/⟨u³⟩

IEEE Access, 2020
Let Z = Fpm[u]/(u3) be the finite commutative chain ring, where p is a prime, m is a positive integer and Fpm is the finite field with pm elements. In this paper, we determine all repeated-root constacyclic codes of arbitrary lengths over Z and their ...
Tania Sidana, Anuradha Sharma
doaj   +1 more source