Results 41 to 50 of about 32,428 (257)

Effect of Cyclic Loading Treatment on the Compression Energy and Creep Properties of Machine-Harvested Seed Cotton

Agriculture
Machine-harvested seed cotton was taken as the research object to further clarify its creep performance, minimize its power consumption during the loading process, and obtain a better loading method.
Ximei Wei, Meng Wang, Hongwen Zhang, Lei Wang, Xintian Du, Lixin Chen, Shaohua Zhi   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Research on the 2A11 Aluminum Alloy Sheet Cyclic Tension–Compression Test and Its Application in a Mixed Hardening Model

Metals, 2023
The increasing application of aluminum alloy, in combination with the growth in the complexity of components, provides new challenges for the numerical modeling of sheet materials.
Guang Chen, Changcai Zhao, Haiwei Shi, Qingxing Zhu, Guoyi Shen, Zheng Liu, Chenyang Wang, Duan Chen   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Compression of quasianalytic spectral sets of cyclic contractions [PDF]

Journal of Functional Analysis, 2012
Let \(\mathcal{H}\) be an infinite-dimensional separable Hilbert space. For \(T\) a bounded linear operator on \(\mathcal{H}\), recall that a closed subspace \(W\subset\mathcal{H}\) is a hyperinvariant subspace of \(T\) if \(W\) is invariant under any operator commuting with \(T\).
Kérchy László, Totik Vilmos
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Wetting-drying-freezing-thawing cycle effect on the hydro-mechanical behaviour of Yanji swelling mudstone

Journal of Rock Mechanics and Geotechnical Engineering, 2023
Swelling geomaterials in northwestern and northeastern China are exposed to both seasonal wetting-drying (DW) and freezing-thawing (FT) processes. The influence of full-process wetting-drying-freezing-thawing (WDFT) cycles on their hydro-mechanical ...
Zhixiong Zeng, Lingwei Kong
doaj   +1 more source