Results 101 to 110 of about 20,142 (297)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Deformation Characteristics of Soft Marine Soil Tested under Cyclic Loading with Low Frequency
Advances in Civil Engineering, 2020 Soft marine soil which could be found widely at the coastal and offshore areas is usually associated with high settlement and instability, especially under cyclic loading. Many research studies have been conducted on its deformation characteristics under
Yu Lu, Wenbin Fu, Danxuan Xue
doaj +1 more source
Fuzzy simulation of forest road surface parameters [PDF]
, 2019 The problem of construction of forest roads with the use of local low-strength substandard materials and industrial waste is considered. To solve the problem, the primary task is to develop a method for estimating the parameters of road surfaces taking ...
Kovalev, R. N. +2 more
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Experimental study on the effect of confining pressure and interval time on the fatigue mechanical properties of mudstone [PDF]
E3S Web of ConferencesThe mudstone interlayer experiences discontinuous cyclic loading during gas storage reservoir operation. To investigate the effects of intermittent action and confining pressure on the fatigue mechanical properties of mudstone.
Zhang Yuhao +3 more
doaj +1 more source
, 1976 A solar powered pump particularly suited for intermittently delivering a stream of water is reported. The pump is characterized by a housing adapted to be seated in a source of water having a water discharge port disposed above the water line of the ...
Kirsten, C. C.
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Development and mechanical properties of construction materials from lunar simulants [PDF]
The development of construction materials such as concrete from lunar soils without the use of water requires a different methodology than that used for conventional terrestrial concrete. Currently, this research involves two aspects: (1) liquefaction of
Desai, Chandra S.
core +1 more source