Results 51 to 60 of about 103,875 (262)
Development of 153Sm-DTPA-SPION as a theranostic dual contrast agents in SPECT/MRI [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): This study describes the preparation, biodistribution of 153Sm-DTPA-SPION after intravenous injection in rats. Materials and Methods: The chelator DTPA dianhydride was conjugated to SPION using a small modification of the well-known cyclic ...
Amir Gholami +1 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Antibiotics, 2022 Bacterial resistance is a growing global concern necessitating the discovery and development of antibiotics effective against the drug-resistant bacterial strain.
Muhammad Imran Sajid +3 more
doaj +1 more source
Half-BPS M2-brane orbifolds [PDF]
, 2010 Smooth Freund-Rubin backgrounds of eleven-dimensional supergravity of the form AdS_4 x X^7 and preserving at least half of the supersymmetry have been recently classified.
de Medeiros, Paul +1 more
core +2 more sources
Cyclic cohomology for graded $C^{*,r}$-algebras and its pairings with van Daele $K$-theory
, 2019 We consider cycles for graded $C^{*,r}$-algebras (Real $C^{*}$-algebras) which are compatible with the $*$-structure and the real structure. Their characters are cyclic cocycles. We define a Connes type pairing between such characters and elements of the
Kellendonk, Johannes
core +2 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Comparison of Cyclic and Linear PEG Conjugates [PDF]
Bioconjugate ChemistryBioconjugation of polymers to proteins is a method to impart improved stability and pharmacokinetic properties to biologic systems. However, the precise effects of polymer architecture on the resulting bioconjugates are not well understood. Particularly, cyclic polymers are known to possess unique features such as a decreased hydrodynamic radius when ...
Grace E. Kunkel +8 more
openaire +3 more sources
Synthesis of Peptidomimetic Conjugates of Cyclic Nucleoside Phosphonates [PDF]
Current Protocols in Nucleic Acid Chemistry, 2010 AbstractCyclic nucleoside phosphonates connected through a P‐O‐C linkage to a promoiety represent a class of prodrugs designed to overcome the low oral bioavailability of parent antiviral acyclic nucleoside phosphonates. In our prodrug approach, a nontoxic promoiety, such as an amino acid or dipeptide, is conjugated to the cyclic form of the parent ...
Michaela, Serpi +3 more
openaire +2 more sources