Results 61 to 70 of about 104,780 (277)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Simple One-Step Method to Synthesize Polypyrrole-Indigo Carmine-Silver Nanocomposite

open access: yesJournal of Chemistry, 2016
A nanocomposite of indigo carmine doped polypyrrole/silver nanoparticles was obtained by a one-step electrochemical process. The nanocomposite was characterized by scanning electron microscopy, infrared spectroscopy, ultraviolet-visible-near infrared ...
Lara Fernandes Loguercio   +5 more
doaj   +1 more source

Electrochemical Behavior and Antioxidant and Prooxidant Activity of Natural Phenolics

open access: yesMolecules, 2007
We have investigated the electrochemical oxidation of a number natural phenolics (salicylic acid, m-hydroxybenzoic acid, p-hydroxybenzoic acid, protocatechuic acid, o-coumaric acid, m-coumaric acid, p-coumaric acid, caffeic acid, quercetin and rutin ...
Marija Todorović   +3 more
doaj   +1 more source

Genericity of Filling Elements [PDF]

open access: yes, 2010
An element of a finitely generated non-Abelian free group F(X) is said to be filling if that element has positive translation length in every very small action of F(X) on an $\mathbb{R}$-tree.
Solie, Brent B.
core  

Concordance group and stable commutator length in braid groups

open access: yes, 2014
We define a quasihomomorphism from braid groups to the concordance group of knots and examine its properties and consequences of its existence. In particular, we provide a relation between the stable four ball genus in the concordance group and the ...
Brandenbursky, Michael, Kędra, Jarek
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Why is phenanthrene more stable than anthracene?

open access: yesMacedonian Journal of Chemistry and Chemical Engineering, 2007
By means of a recently developed molecular-orbital-based method it is possible to estimate the energy effects of individual cycles, as well as pairs, triplets, etc. of cycles in polycyclic conjugated molecules.
Ivan Gutman, Sonja Stanković
doaj   +1 more source

Half-BPS M2-brane orbifolds [PDF]

open access: yes, 2010
Smooth Freund-Rubin backgrounds of eleven-dimensional supergravity of the form AdS_4 x X^7 and preserving at least half of the supersymmetry have been recently classified.
de Medeiros, Paul   +1 more
core   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

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