Results 51 to 60 of about 104,780 (277)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Development of 153Sm-DTPA-SPION as a theranostic dual contrast agents in SPECT/MRI [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): This study describes the preparation, biodistribution of 153Sm-DTPA-SPION after intravenous injection in rats. Materials and Methods: The chelator DTPA dianhydride was conjugated to SPION using a small modification of the well-known cyclic ...
Amir Gholami +1 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Cohomological Finiteness Conditions in Bredon Cohomology
, 2009 We show that any soluble group $G$ of type Bredon-$\FP_{\infty}$ with respect to the family of all virtually cyclic subgroups such that centralizers of infinite order elements are of type $\FP_{\infty}$ must be virtually cyclic.
Kochloukova, D. H. +2 more
core +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Cyclic surfaces and Hitchin components in rank 2 [PDF]
, 2016 We prove that given a Hitchin representation in a real split rank 2 group $\mathsf G_0$, there exists a unique equivariant minimal surface in the corresponding symmetric space.
Labourie, François
core
On the automorphisms of a graph product of abelian groups
, 2007 We study the automorphisms of a graph product of finitely-generated abelian groups W. More precisely, we study a natural subgroup Aut* W of Aut W, with Aut* W = Aut W whenever vertex groups are finite and in a number of other cases.
Gutierrez, Mauricio +2 more
core +2 more sources
Comparison of Cyclic and Linear PEG Conjugates [PDF]
Bioconjugate ChemistryBioconjugation of polymers to proteins is a method to impart improved stability and pharmacokinetic properties to biologic systems. However, the precise effects of polymer architecture on the resulting bioconjugates are not well understood. Particularly, cyclic polymers are known to possess unique features such as a decreased hydrodynamic radius when ...
Grace E. Kunkel +8 more
openaire +3 more sources
Synthesis of Peptidomimetic Conjugates of Cyclic Nucleoside Phosphonates [PDF]
Current Protocols in Nucleic Acid Chemistry, 2010 AbstractCyclic nucleoside phosphonates connected through a P‐O‐C linkage to a promoiety represent a class of prodrugs designed to overcome the low oral bioavailability of parent antiviral acyclic nucleoside phosphonates. In our prodrug approach, a nontoxic promoiety, such as an amino acid or dipeptide, is conjugated to the cyclic form of the parent ...
Michaela, Serpi +3 more
openaire +2 more sources