Results 81 to 90 of about 304 (209)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Phospholipid-independent biogenesis and function of the RP4 conjugation pilus

Nature Communications
Bacterial conjugation, the process of horizontal gene transfer between bacteria, is initiated by mating pair formation (MPF) via a conjugative pilus. Conjugation of the IncP RP4 plasmid is mediated by short mating pili.
Naito Ishimoto, Shan He, Mikhail Bogdanov, Terry K. Smith, Gad Frankel, Konstantinos Beis   +5 more
doaj   +1 more source

Synthesis of 4, 4'-Stilbene Dicarboxylic Acid and Aniline Modified Graphene Oxide and Its Electrochemical Performance for Supercapacitors

International Journal of Electrochemical Science, 2016
Graphene oxide obtained through liquid ex-foliation of graphite flakes by improved Hammer's method have been functionalized with stilbene-4, 4'-dicarboxylic acid and aniline and electrochemical performance of covalently functionalized graphene oxide was ...
Asim Riaz, Adil Usman, Zakir Hussain
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Renal Clearable H‐Dots Leveraging Ligand Complexation for Enhanced Active Tumor Targeting

Small Science
The use of ligand conjugation onto nanoparticle surfaces as an active targeting strategy has gained significant attention in the pursuit of improving tumor‐specific delivery and retention.
Yanan Cui, Seung Hun Park, Wesley R. Stiles, Atsushi Yamashita, Jason Dinh, Richard S. Kim, Yadong Zhang, Xiaoran Yin, Yoonji Baek, Haoran Wang, Kai Bao, Homan Kang, Hak Soo Choi   +12 more
doaj   +1 more source

Peptide Coacervates Promote Cytosolic Delivery of STING Agonists for Cancer Immunotherapy

Vaccines
Background/Objectives: Cyclic dinucleotide stimulator of interferon genes (STING) agonists have emerged as potential agents in cancer immunotherapy, but their clinical applications are limited by relatively poor pharmacokinetic properties.
Wenlv Zheng, Wei Tang, Jianzheng Wang, Yurong Li, Shengnan Wang, Dan Wu, Xiaoquan Wang, Junmin Quan   +7 more
doaj   +1 more source

Cyclic Conjugation in Porphin

Croatica Chemica Acta, 1986
The paper consists of three parts. In Part A the cyclic conjugation in porphin and some related compounds is examined. It is shown that the Huckel (4m+2)-rule isviolated so that conjugation along both 16-, 17-, 18-, 19- and 20- membered cycles causes stabilization of the rc-electron system of porphin.
openaire   +2 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Development of Radiolabeled Recombinant Erythropoietin for Receptor Studies [PDF]

مجله علوم و فنون هسته‌ای, 2012
The study of human erythropoietin receptor is of great importance in evolution, carcinogenesis as well as endocrine research. In this study the production and quality control of human recombinant erythropoietin (EPO) has been reported.
A.R. Jalilian, H. H. Sadeghpour, M Akhlaghi, E Gholami   +3 more
doaj